NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NUCKS1provided by HGNC
Official Full Name: nuclear casein kinase and cyclin dependent kinase substrate 1provided by HGNC
Primary source: HGNC:HGNC:29923
See related: Ensembl:ENSG00000069275 MIM:611912; AllianceGenome:HGNC:29923
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JC7; NUCKS
Summary: This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]
Expression: Ubiquitous expression in brain (RPKM 77.7), thyroid (RPKM 69.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q32.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (205712822..205750182, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (204977487..205014861, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (205681950..205719310, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NUCB2 inhibition antagonizes osteosarcoma progression and promotes anti-tumor immunity through inactivating NUCKS1/CXCL8 axis.
Title: NUCB2 inhibition antagonizes osteosarcoma progression and promotes anti-tumor immunity through inactivating NUCKS1/CXCL8 axis.
NUCKS1 Acts as a Promising Novel Biomarker for the Prognosis of Patients with Hepatocellular Carcinoma.
Title: NUCKS1 Acts as a Promising Novel Biomarker for the Prognosis of Patients with Hepatocellular Carcinoma.
Roles of increased NUCKS1 expression in endometriosis.
Title: Roles of increased NUCKS1 expression in endometriosis.
NUCKS1 promotes the progression of colorectal cancer via activating PI3K/AKT/mTOR signaling pathway.
Title: NUCKS1 promotes the progression of colorectal cancer via activating PI3K/AKT/mTOR signaling pathway.
miR-641 Inhibited Cell Proliferation and Induced Apoptosis by Targeting NUCKS1/PI3K/AKT Signaling Pathway in Breast Cancer.
Title: miR-641 Inhibited Cell Proliferation and Induced Apoptosis by Targeting NUCKS1/PI3K/AKT Signaling Pathway in Breast Cancer.
CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer.
Title: CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer.
Nucks1 gene polymorphism rs823114 is associated with the positive symptoms and neurocognitive function of patients with schizophrenia in parts of southern China.
Title: Nucks1 gene polymorphism rs823114 is associated with the positive symptoms and neurocognitive function of patients with schizophrenia in parts of southern China.
The NUCKS1-SKP2-p21/p27 axis controls S phase entry.
Title: The NUCKS1-SKP2-p21/p27 axis controls S phase entry.
NUCKS Promotes the Proliferation, Migration and Invasion of Lung Cancer Cells Through Pi3k/Akt Signalling Pathway.
Title: NUCKS Promotes the Proliferation, Migration and Invasion of Lung Cancer Cells Through Pi3k/Akt Signalling Pathway.
NUCKS promotes cell proliferation and suppresses autophagy through the mTOR-Beclin1 pathway in gastric cancer.
Title: NUCKS promotes cell proliferation and suppresses autophagy through the mTOR-Beclin1 pathway in gastric cancer.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study reveals genetic risk underlying Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	NUCKS1 enhances HIV-1 Tat-mediated transcriptional activation on the HIV-1 LTR, and knockdown of NUCKS1 by siRNA significantly reduces Tat-mediated transcriptional activation	PubMed
	tat	HIV-1 Tat interacts directly with both ectopically expressed and endogenous NUCKS1 in HEK293 cells	PubMed
capsid	gag	Overexpression of NUCKS1 moderately induces HIV-1 production with increased release of p24 without PMA stimulation in latently infected cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-30044 (e-PCR)
- UniSTS:64768

D1S1948E (e-PCR)
- UniSTS:151301

RH68392 (e-PCR)
- UniSTS:14347

G60432 (e-PCR)
- UniSTS:137538

SHGC-79193 (e-PCR)
- UniSTS:102736

D1S3583 (e-PCR)
- UniSTS:78187

D1S1909E (e-PCR)
- UniSTS:36735

D1S249 (e-PCR), detects polymorphism
- UniSTS:73353

SHGC-76252 (e-PCR)
- UniSTS:23724

G34857 (e-PCR)
- UniSTS:63149

RH98313 (e-PCR)
- UniSTS:86703

RH98819 (e-PCR)
- UniSTS:88752

SHGC-76245 (e-PCR)
- UniSTS:1721

G34864 (e-PCR)
- UniSTS:37081

EST5G8 (e-PCR)
- UniSTS:263388

SHGC-76227 (e-PCR)
- UniSTS:57575

SHGC-32226 (e-PCR)
- UniSTS:14313

D1S2379 (e-PCR)
- UniSTS:6910

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	HDA more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene conversion	NAS Non-traceable Author Statement more info	PubMed
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation by host of RNA binding by virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation by host of viral RNA-binding transcription factor activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in modulation by host of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation by host of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation by host of viral transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA strand elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork processing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Names: P1; nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate; potential LAG1 interactor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.