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    ALR1 Mg(2+) transporter ALR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853990, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ALR1
    Official Full Name
    Mg(2+) transporter ALR1
    Primary source
    SGD:S000005490
    Locus tag
    YOL130W
    See related
    AllianceGenome:SGD:S000005490; FungiDB:YOL130W; VEuPathDB:YOL130W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SWC3
    Summary
    Enables inorganic cation transmembrane transporter activity. Involved in magnesium ion transport. Located in plasma membrane. Used to study primary hypomagnesemia. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ALR1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (74400..76979)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene 1,3-beta-glucanosyltransferase Neighboring gene uncharacterized protein Neighboring gene Vps68p Neighboring gene serine/threonine protein kinase YGK3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast plasma membrane protein Alr1 controls Mg2+ homeostasis and is subject to Mg2+-dependent control of its synthesis and degradation. Graschopf A, et al. J Biol Chem, 2001 May 11. PMID 11279208
    2. Residues of the yeast ALR1 protein that are critical for magnesium uptake. Lee JM, et al. Curr Genet, 2006 Jan. PMID 16328501
    3. The bacterial magnesium transporter CorA can functionally substitute for its putative homologue Mrs2p in the yeast inner mitochondrial membrane. Bui DM, et al. J Biol Chem, 1999 Jul 16. PMID 10400670
    4. Flavin-linked Erv-family sulfhydryl oxidases release superoxide anion during catalytic turnover. Daithankar VN, et al. Biochemistry, 2012 Jan 10. PMID 22148553, Free PMC Article
    5. Manipulation of intracellular magnesium levels in Saccharomyces cerevisiae with deletion of magnesium transporters. da Costa BM, et al. Appl Microbiol Biotechnol, 2007 Nov. PMID 17926032

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alr1 is required for the up-regulation of the Mg(2+) content in polyamine-depleted cells
      Title: Elevation of cellular Mg(2+) levels by the Mg(2+) transporter, Alr1, supports growth of polyamine-deficient Saccharomyces cerevisiae cells.
    2. Superoxide is released at the level of Erv/ALR monomers and does not require the obligatory involvement of dimeric forms of these proteins as they reduce the superoxide ion and release up to ~30% of the oxygen.
      Title: Flavin-linked Erv-family sulfhydryl oxidases release superoxide anion during catalytic turnover.
    3. Data conclude that variation in Alr1 protein accumulation or location does not make a substantial contribution to its regulation by Mg supply, suggesting Alr1 activity is directly regulated via as yet unknown mechanisms.
      Title: Regulation of Alr1 Mg transporter activity by intracellular magnesium.
    4. High expression of inactive mutants inhibited the capability of wild-type Alr1 to transport magnesium, consistent with Alr1 forming homo-oligomers. The results confirm the classification of ALR1 as a member of the CorA family of magnesium transport genes.
      Title: Residues of the yeast ALR1 protein that are critical for magnesium uptake.
    5. Alr1p and Alr2p are shown here to be present in the plasma membrane and shown to form homo-oligomers as well as hetero-oligomers; both the N-terminus and C-terminus of Alr1p and Alr2p are exposed to the inner side of the plasma membrane
      Title: Oligomerization of the Mg2+-transport proteins Alr1p and Alr2p in yeast plasma membrane.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables inorganic cation transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables magnesium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular magnesium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic cation transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mg(2+) transporter ALR1
    NP_014511.1
    • Plasma membrane Mg(2+) transporter; expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; magnesium transport defect of the null mutant is functionally complemented by either of the human genes MAGT1 and TUSC3 that are not orthologous to ALR1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      74400..76979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183384.1 → NP_014511.1  TPA: Mg(2+) transporter ALR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014511.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1T8, Q02811, Q08269
      UniProtKB/TrEMBL
      B5VRC8, C7GV06, N1NYL1
      Conserved Domains (1) summary
      cd12829
      Location:456 → 779
      Alr1p-like; Saccharomyces cerevisiae Alr1p-like subfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08269.1

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