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    SLC35B4 solute carrier family 35 member B4 [ Homo sapiens (human) ]

    Gene ID: 84912, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SLC35B4provided by HGNC
    Official Full Name
    solute carrier family 35 member B4provided by HGNC
    Primary source
    HGNC:HGNC:20584
    See related
    Ensembl:ENSG00000205060 MIM:610923; AllianceGenome:HGNC:20584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YEA; YEA4
    Summary
    Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 6.0), brain (RPKM 5.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC35B4 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (134289332..134320338, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (135597448..135628436, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (133974084..134001682, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene exocyst complex component 4 Neighboring gene uncharacterized LOC105375514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26688 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:133814671-133815405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18670 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:133874107-133874656 Neighboring gene leucine rich repeats and guanylate kinase domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18672 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26689 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:134050229-134051428 Neighboring gene uncharacterized LOC105375518 Neighboring gene uncharacterized LOC105375517 Neighboring gene long intergenic non-protein coding RNA 3060

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular and functional characterization of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family. Kobayashi T, et al. Biochem J, 2006 Dec 1. PMID 16965264, Free PMC Article
    2. A common regulatory variant in SLC35B4 influences the recurrence and survival of prostate cancer. Huang EY, et al. J Cell Mol Med, 2018 Jul. PMID 29682886, Free PMC Article
    3. Lysine at position 329 within a C-terminal dilysine motif is crucial for the ER localization of human SLC35B4. Bazan B, et al. PLoS One, 2018. PMID 30458018, Free PMC Article
    4. SLC35B4, an Inhibitor of Gluconeogenesis, Responds to Glucose Stimulation and Downregulates Hsp60 among Other Proteins in HepG2 Liver Cell Lines. Wex B, et al. Molecules, 2018 Jun 4. PMID 29867058, Free PMC Article
    5. A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma. Liu J, et al. Cell Death Dis, 2019 Jun 7. PMID 31175271, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel YAP1/SLC35B4 axis promotes gastric cancer (GC) development and progression, and this axis could be a potential candidate for prognosis and therapeutics in GC.
      Title: A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma.
    2. SLC35B4 single nucleotide polymorphism rs1646724 was associated with recurrence in patients with localized disease and survival in patients with advanced prostate cancer.
      Title: A common regulatory variant in SLC35B4 influences the recurrence and survival of prostate cancer.
    3. Our data showed that knock-out of the SLC35B4 gene does not affect major UDP-Xyl- and UDP-GlcNAc-dependent glycosylation pathways.
      Title: Lysine at position 329 within a C-terminal dilysine motif is crucial for the ER localization of human SLC35B4.
    4. Glucose levels activate SLC35B4 expression. This triggers a downstream effect via Hsp60 and other proteins. We hypothesize that the downstream effect on the proteins is mediated via altering the glycosylation pattern inside liver cells
      Title: SLC35B4, an Inhibitor of Gluconeogenesis, Responds to Glucose Stimulation and Downregulates Hsp60 among Other Proteins in HepG2 Liver Cell Lines.
    5. subcellular localization of SLC35B4
      Title: Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4 transporters.
    6. Decreased SLC35B4 expression led to increased gluconeogenesis in HepG2 cells.
      Title: Deep congenic analysis identifies many strong, context-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeostasis.
    7. Transport capabilities for UDP-Glc and UDP-Xyl were determined with Golgi vesicles isolated from transformed cells
      Title: The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14697

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables UDP-xylose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-xylose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-xylose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-N-acetylglucosamine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-xylose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleotide sugar transporter SLC35B4
    Names
    UDP-Xylose/N-Acetylglucosamine transporter
    UDP-xylose and UDP-N-acetylglucosamine transporter
    YEA4 homolog
    solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032826.5 → NP_116215.1  nucleotide sugar transporter SLC35B4

      See identical proteins and their annotated locations for NP_116215.1

      Status: VALIDATED

      Source sequence(s)
      AB052892, AC008154
      Consensus CDS
      CCDS34756.1
      UniProtKB/Swiss-Prot
      A4D1P3, A6NNS4, Q53GQ7, Q8TCU7, Q969S0, Q96K33
      Related
      ENSP00000367770.4, ENST00000378509.9
      Conserved Domains (1) summary
      pfam08449
      Location:2 → 314
      UAA; UAA transporter family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      134289332..134320338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516645.4 → XP_011514947.1  nucleotide sugar transporter SLC35B4 isoform X1

      Conserved Domains (2) summary
      pfam08449
      Location:28 → 314
      UAA; UAA transporter family
      cl23754
      Location:87 → 310
      EamA; EamA-like transporter family

    2. XM_047420996.1 → XP_047276952.1  nucleotide sugar transporter SLC35B4 isoform X2

    RNA

    1. XR_001744890.3 RNA Sequence

    2. XR_001744889.3 RNA Sequence

    3. XR_001744888.3 RNA Sequence

    4. XR_001744887.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      135597448..135628436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359276.1 → XP_054215251.1  nucleotide sugar transporter SLC35B4 isoform X1

    2. XM_054359277.1 → XP_054215252.1  nucleotide sugar transporter SLC35B4 isoform X2

    RNA

    1. XR_008487771.1 RNA Sequence

    2. XR_008487772.1 RNA Sequence

    3. XR_008487770.1 RNA Sequence

    4. XR_008487769.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q969S0.1 GenPept UniProtKB/Swiss-Prot:Q969S0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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