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    DOK1 docking protein 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 483100, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DOK1provided by VGNC
    Official Full Name
    docking protein 1provided by VGNC
    Primary source
    VGNC:VGNC:40055
    See related
    Ensembl:ENSCAFG00845017897
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See DOK1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (49448003..49453227, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (48230464..48235681, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (49089579..49094795, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (48465182..48470394, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (48531935..48537130, complement)

    Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene meiosis 1 associated protein Neighboring gene vesicle-associated membrane protein 3-like Neighboring gene S-phase kinase-associated protein 1-like Neighboring gene lysyl oxidase like 3 Neighboring gene HtrA serine peptidase 2 Neighboring gene AUP1 lipid droplet regulating VLDL assembly factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    docking protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051821.1 Reference ROS_Cfam_1.0

      Range
      49448003..49453227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038691631.1 → XP_038547559.1  docking protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0QIN9
      Conserved Domains (2) summary
      cd01203
      Location:138 → 240
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:2 → 106
      PH-like; Pleckstrin homology-like domain

    2. XM_038691630.1 → XP_038547558.1  docking protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KPY7, A0A8C0QIN9, A0A8C0QNF4
      Related
      ENSCAFP00845024848.1, ENSCAFT00845031749.1
      Conserved Domains (2) summary
      cd01203
      Location:151 → 253
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:6 → 119
      PH-like; Pleckstrin homology-like domain

    3. XM_038691632.1 → XP_038547560.1  docking protein 1 isoform X3

      Conserved Domains (1) summary
      cd01203
      Location:12 → 114
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049277.1 Alternate UMICH_Zoey_3.1

      Range
      48465182..48470394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038499082.1 → XP_038355010.1  docking protein 1 isoform X2

      Conserved Domains (2) summary
      cd01203
      Location:138 → 240
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:2 → 106
      PH-like; Pleckstrin homology-like domain

    2. XM_038499081.1 → XP_038355009.1  docking protein 1 isoform X1

      Conserved Domains (2) summary
      cd01203
      Location:151 → 253
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:6 → 119
      PH-like; Pleckstrin homology-like domain

    3. XM_038499083.1 → XP_038355011.1  docking protein 1 isoform X3

      Conserved Domains (1) summary
      cd01203
      Location:12 → 114
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

      Range
      48531935..48537130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038625703.1 → XP_038481631.1  docking protein 1 isoform X2

      Conserved Domains (2) summary
      cd01203
      Location:138 → 240
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:2 → 106
      PH-like; Pleckstrin homology-like domain

    2. XM_038625702.1 → XP_038481630.1  docking protein 1 isoform X1

      Conserved Domains (2) summary
      cd01203
      Location:151 → 253
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:6 → 119
      PH-like; Pleckstrin homology-like domain

    3. XM_038625704.1 → XP_038481632.1  docking protein 1 isoform X3

      Conserved Domains (1) summary
      cd01203
      Location:12 → 114
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

      Range
      49089579..49094795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038561671.1 → XP_038417599.1  docking protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0QIN9
      Conserved Domains (2) summary
      cd01203
      Location:138 → 240
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:2 → 106
      PH-like; Pleckstrin homology-like domain

    2. XM_038561670.1 → XP_038417598.1  docking protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KPY7, A0A8C0QIN9, A0A8C0QNF4
      Conserved Domains (2) summary
      cd01203
      Location:151 → 253
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:6 → 119
      PH-like; Pleckstrin homology-like domain

    3. XM_038561672.1 → XP_038417600.1  docking protein 1 isoform X3

      Conserved Domains (1) summary
      cd01203
      Location:12 → 114
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      48230464..48235681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038453108.1 → XP_038309036.1  docking protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0QIN9
      Conserved Domains (2) summary
      cd01203
      Location:138 → 240
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:2 → 106
      PH-like; Pleckstrin homology-like domain

    2. XM_540216.7 → XP_540216.5  docking protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KPY7, A0A8C0QIN9, A0A8C0QNF4
      Conserved Domains (2) summary
      cd01203
      Location:151 → 253
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:6 → 119
      PH-like; Pleckstrin homology-like domain

    3. XM_038453109.1 → XP_038309037.1  docking protein 1 isoform X3

      Conserved Domains (1) summary
      cd01203
      Location:12 → 114
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    Nucleotide Protein
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