U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MDM10 Mdm10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851223, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MDM10
    Official Full Name
    Mdm10p
    Primary source
    SGD:S000000008
    Locus tag
    YAL010C
    See related
    AllianceGenome:SGD:S000000008; FungiDB:YAL010C; VEuPathDB:YAL010C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN37
    Summary
    Involved in several processes, including establishment of mitochondrion localization; mitochondrion-endoplasmic reticulum membrane tethering; and outer mitochondrial membrane organization. Located in mitochondrial outer membrane. Part of ERMES complex and SAM complex. [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MDM10 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (134184..135665, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene cystathionine gamma-lyase CYS3 Neighboring gene Swc3p Neighboring gene Nem1-Spo7 phosphatase regulatory subunit SPO7 Neighboring gene Fun14p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mdm10 is an ancient eukaryotic porin co-occurring with the ERMES complex. Flinner N, et al. Biochim Biophys Acta, 2013 Dec. PMID 24135058
    2. Mutations in genes encoding the mitochondrial outer membrane proteins Tom70 and Mdm10 of Podospora anserina modify the spectrum of mitochondrial DNA rearrangements associated with cellular death. Jamet-Vierny C, et al. Mol Cell Biol, 1997 Nov. PMID 9343397, Free PMC Article
    3. Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. Sogo LF, et al. J Cell Biol, 1994 Sep. PMID 8089171, Free PMC Article
    4. Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae. Hanekamp T, et al. Genetics, 2002 Nov. PMID 12454062, Free PMC Article
    5. Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p. Boldogh I, et al. J Cell Biol, 1998 Jun 15. PMID 9628893, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tom7 recruits Mdm10, enhancing its association with the MMM1 complex, to regulate timing of the release of Tom40 from the TOB complex for subsequent assembly into the TOM40 complex
      Title: Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40.
    2. Mdm10 regulates the timing of release of unassembled Tom40 from the TOB complex, to facilitate its coordinated assembly into the TOM40 complex
      Title: Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40.
    3. Tom7-mediated segregation of Mdm10 functions by a differentiation of beta-barrel assembly
      Title: Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of mitochondrion localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial outer membrane translocase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial outer membrane translocase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial outer membrane translocase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial outer membrane translocase complex assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into mitochondrial outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ERMES complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ERMES complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ERMES complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of SAM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAM complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Mdm10p
    NP_009392.2
    • Moonlighting protein component of both the ERMES and SAM complex; subunit of the ERMES complex that acts as a molecular tether between the mitochondria and the ER, necessary for both efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex subunit that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; ERMES complex often co-localizes with peroxisomes adjacent to mitochondria-ER junctions

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      134184..135665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178155.2 → NP_009392.2  TPA: Mdm10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009392.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A0F9, D6VPK8, P18409
      UniProtKB/TrEMBL
      N1PAZ3
      Conserved Domains (1) summary
      pfam12519
      Location:1 → 493
      MDM10; Mitochondrial distribution and morphology protein 10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18409.5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools