CLN3 cyclin CLN3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CLN3
Official Full Name: cyclin CLN3
Primary source: SGD:S000000038
Locus tag: YAL040C
See related: AllianceGenome:SGD:S000000038; FungiDB:YAL040C; VEuPathDB:YAL040C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DAF1; FUN10; WHI1
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including G1/S transition of mitotic cell cycle; traversing start control point of mitotic cell cycle; and vacuole fusion, non-autophagic. Located in nucleus. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); endocrine gland cancer (multiple); hematologic cancer (multiple); and hepatitis B. Orthologous to several human genes including CCNA1 (cyclin A1); CCNA2 (cyclin A2); and CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CLN3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (65778..67520, complement)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth.
Title: Growth-dependent signals drive an increase in early G1 cyclin concentration to link cell cycle entry with cell growth.
G1 cyclin-Cdk promotes cell cycle entry through localized phosphorylation of RNA polymerase II.
Title: G(1) cyclin-Cdk promotes cell cycle entry through localized phosphorylation of RNA polymerase II.
Cell volume homeostatically controls the rDNA repeat copy number and rRNA synthesis rate in yeast.
Title: Cell volume homeostatically controls the rDNA repeat copy number and rRNA synthesis rate in yeast.
Pulses in Cln3 concentration are responsible for Start.
Title: Differential scaling between G1 protein production and cell size dynamics promotes commitment to the cell division cycle in budding yeast.
Rim15 activity increases after cells switch from fermentation to respiration, where Igo1,2 contribute to chromosome maintenance. Interestingly Cln3-Cdk1 also inhibits Rim15 activity, which enables homeostatic control of Whi5 phosphorylation and cell cycle entry.
Title: Homeostatic control of START through negative feedback between Cln3-Cdk1 and Rim15/Greatwall kinase in budding yeast.
G0/G1 transition, via Rim 15 and CLN3, might govern the fermentation rate of bottom-fermenting brewer's yeast in high-gravity wort.
Title: Defective quiescence entry promotes the fermentation performance of bottom-fermenting brewer's yeast.
Whi5 phosphorylation by Cln3-Cdk1 embedded in the G1/S network dynamically controls critical cell size and cell fate.
Title: Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate.
In CLN3, Whi3 may bind to the 3' GCAU motifs to attract the Ccr4-Not complex to promote RNA deadenylation and turnover, and Whi3 may bind to the 5' GCAU motifs to inhibit translation.
Title: Effects of the yeast RNA-binding protein Whi3 on the half-life and abundance of CLN3 mRNA and other targets.
T36 phosphorylation triggers displacement of Ydj1, allowing Ssa1 to bind the G1 cyclin Cln3 and promote its degradation; these results establish an active role for Hsp70 chaperones as signal transducers mediating growth control of G1 cyclin abundance and activity
Title: CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression.
we show that Cln3 is redundantly targeted by two F-box proteins with key cell cycle-regulatory roles, Cdc4 and Grr1
Title: F-box protein specificity for g1 cyclins is dictated by subcellular localization.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in traversing start control point of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in traversing start control point of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in traversing start control point of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuole fusion, non-autophagic	IDA Inferred from Direct Assay more info	PubMed
involved_in vacuole fusion, non-autophagic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuole organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cyclin CLN3

NP_009360.1

G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetyl-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

65778..67520 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178185.1 → NP_009360.1 TPA: cyclin CLN3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009360.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPH6, E9P940, P13365

UniProtKB/TrEMBL

B3LUX6, B5VDH7, C7GPJ7, C8Z3E9, N1P920

Conserved Domains (1) summary

COG5024
Location:35 → 576

COG5024; Cyclin [Cell division and chromosome partitioning]