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    SPC72 gamma-tubulin complex subunit SPC72 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851250, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SPC72
    Official Full Name
    gamma-tubulin complex subunit SPC72
    Primary source
    SGD:S000000045
    Locus tag
    YAL047C
    See related
    AllianceGenome:SGD:S000000045; FungiDB:YAL047C; VEuPathDB:YAL047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LDB4
    Summary
    Enables microtubule lateral binding activity and microtubule plus-end binding activity. Involved in gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body; microtubule cytoskeleton organization; and mitotic spindle orientation checkpoint signaling. Located in mitotic spindle astral microtubule end and outer plaque of mitotic spindle pole body. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See SPC72 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (54989..56857, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene protein AIM2 Neighboring gene ERMES complex Ca(2+)-binding regulatory GTPase GEM1 Neighboring gene Bol3p Neighboring gene Bol1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SPC72: a spindle pole component required for spindle orientation in the yeast Saccharomyces cerevisiae. Souès S, et al. J Cell Sci, 1998 Sep. PMID 9718373
    2. Stu2p: A microtubule-binding protein that is an essential component of the yeast spindle pole body. Wang PJ, et al. J Cell Biol, 1997 Dec 1. PMID 9382872, Free PMC Article
    3. Mitotic exit network controls the localization of Cdc14 to the spindle pole body in Saccharomyces cerevisiae. Yoshida S, et al. Curr Biol, 2002 Jun 4. PMID 12062061
    4. Nud1p, the yeast homolog of Centriolin, regulates spindle pole body inheritance in meiosis. Gordon O, et al. EMBO J, 2006 Aug 23. PMID 16888627, Free PMC Article
    5. Spatial cues and not spindle pole maturation drive the asymmetry of astral microtubules between new and preexisting spindle poles. Lengefeld J, et al. Mol Biol Cell, 2018 Jan 1. PMID 29142076, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast.
      Title: The Spo13/Meikin pathway confines the onset of gamete differentiation to meiosis II in yeast.
    2. Functions of Nud1p are connected to the ability of Spc72p to bind to the outer plaque and half-bridge (via Kar1p) of the SPB.
      Title: Nud1p, the yeast homolog of Centriolin, regulates spindle pole body inheritance in meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables microtubule lateral binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in astral microtubule anchoring at mitotic spindle pole body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in karyogamy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle orientation checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic spindle orientation checkpoint signaling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle astral microtubule end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer plaque of mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-tubulin complex subunit SPC72
    NP_009352.2
    • Gamma-tubulin small complex (gamma-TuSC) receptor; recruits the gamma-TuSC complex to the cytoplasmic side of the SPB, connecting nuclear microtubules to the SPB; involved in astral microtubule formation, stabilization, and with Stu2p, anchoring astral MTs at the cytoplasmic face of the SPB, and regulating plus-end MT dynamics; regulated by Cdc5 kinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      54989..56857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178192.2 → NP_009352.2  TPA: gamma-tubulin complex subunit SPC72 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009352.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPG9, E9P941, P39723
      UniProtKB/TrEMBL
      G2W8I3
      Conserved Domains (2) summary
      TIGR02169
      Location:295 → 578
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam12808
      Location:573 → 614
      Mto2_bdg; Micro-tubular organizer Mto1 C-term Mto2-binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39723.2

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