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    YAT1 carnitine O-acetyltransferase YAT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851285, updated on 2-Nov-2024

    Summary

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    Official Symbol
    YAT1
    Official Full Name
    carnitine O-acetyltransferase YAT1
    Primary source
    SGD:S000000080
    Locus tag
    YAR035W
    See related
    AllianceGenome:SGD:S000000080; FungiDB:YAR035W; VEuPathDB:YAR035W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable carnitine O-acetyltransferase activity and carnitine O-palmitoyltransferase activity. Involved in carnitine metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in brain disease; lipid metabolism disorder; and muscular disease. Orthologous to human CPT2 (carnitine palmitoyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See YAT1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (190193..192256)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene pheromone-regulated DUP240 family protein PRM9 Neighboring gene DUP240 family protein MST28 Neighboring gene uncharacterized protein Neighboring gene oxysterol-binding protein related protein SWH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ethanol-inducible YAT1 gene from yeast encodes a presumptive mitochondrial outer carnitine acetyltransferase. Schmalix W, et al. J Biol Chem, 1993 Dec 25. PMID 8262985
    2. Presence of carnitine acetyltransferase in peroxisomes and in mitochondria of oleic acid-grown Saccharomyces cerevisiae. Atomi H, et al. FEMS Microbiol Lett, 1993 Aug 15. PMID 8405946
    3. A glimpse of potential transposable element impact on adaptation of the industrial yeast Saccharomyces cerevisiae. Liu ZL, et al. FEMS Yeast Res, 2020 Sep 1. PMID 32780789
    4. Cloning and sequencing of a cDNA encoding Saccharomyces cerevisiae carnitine acetyltransferase. Use of the cDNA in gene disruption studies. Kispal G, et al. J Biol Chem, 1993 Jan 25. PMID 8420957
    5. Carnitine-dependent metabolic activities in Saccharomyces cerevisiae: three carnitine acetyltransferases are essential in a carnitine-dependent strain. Swiegers JH, et al. Yeast, 2001 May. PMID 11329169

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carnitine O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carnitine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carnitine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carnitine O-acetyltransferase YAT1
    NP_009420.1
    • Outer mitochondrial carnitine acetyltransferase; minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      190193..192256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178226.1 → NP_009420.1  TPA: carnitine O-acetyltransferase YAT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPN4, P80235
      UniProtKB/TrEMBL
      C7GJW6, C8Z3J3, G2W8P8
      Conserved Domains (1) summary
      pfam00755
      Location:4 → 642
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80235.2

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