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    MNN2 alpha-1,2-mannosyltransferase MNN2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852303, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MNN2
    Official Full Name
    alpha-1,2-mannosyltransferase MNN2
    Primary source
    SGD:S000000219
    Locus tag
    YBR015C
    See related
    AllianceGenome:SGD:S000000219; FungiDB:YBR015C; VEuPathDB:YBR015C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CRV4; LDB8; TTP1
    Summary
    Enables alpha-1,2-mannosyltransferase activity. Involved in protein glycosylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MNN2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (267710..269503, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene glutathione-disulfide reductase GRX7 Neighboring gene cysteine-rich palmitoylated domain-containing protein CPP1 Neighboring gene Kap104p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a gene and protein required for glycosylation in the yeast Golgi. Devlin C, et al. Mol Microbiol, 1990 Nov. PMID 2082155
    2. Localization of alpha 1----3-linked mannoses in the N-linked oligosaccharides of Saccharomyces cerevisiae mnn mutants. Alvarado E, et al. Biochemistry, 1990 Mar 13. PMID 2185827
    3. Regulation of the protein glycosylation pathway in yeast: structural control of N-linked oligosaccharide elongation. Gopal PK, et al. Proc Natl Acad Sci U S A, 1987 Dec. PMID 3321055, Free PMC Article
    4. Carbohydrate structure of Saccharomyces cerevisiae mnn9 mannoprotein. Tsai PK, et al. J Biol Chem, 1984 Mar 25. PMID 6368551
    5. The nucleotide sequence of TTP1, a gene encoding a predicted type II membrane protein. Romero PA, et al. Yeast, 1994 Aug. PMID 7992511

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,2-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mannan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,2-mannosyltransferase MNN2
    NP_009571.1
    • Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      267710..269503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178363.1 → NP_009571.1  TPA: alpha-1,2-mannosyltransferase MNN2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009571.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ17, P38069
      UniProtKB/TrEMBL
      A6ZKW1, B3LNC6, C7GM37, C8Z409
      Conserved Domains (1) summary
      pfam11051
      Location:170 → 440
      Mannosyl_trans3; Mannosyltransferase putative
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38069.1

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