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    MUM2 Mum2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852348, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MUM2
    Official Full Name
    Mum2p
    Primary source
    SGD:S000000261
    Locus tag
    YBR057C
    See related
    AllianceGenome:SGD:S000000261; FungiDB:YBR057C; VEuPathDB:YBR057C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mRNA methylation; negative regulation of pseudohyphal growth; and premeiotic DNA replication. Located in cytoplasm. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MUM2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (352193..353293, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene Mnc1p Neighboring gene ubiquitin-specific protease UBP14 Neighboring gene Tsc3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The isolation and genetic analysis of sporulation-deficient mutants in Saccharomyces cerevisiae. Tsuboi M. Mol Gen Genet, 1983. PMID 6350825
    2. Widespread Prion-Based Control of Growth and Differentiation Strategies in Saccharomyces cerevisiae. Itakura AK, et al. Mol Cell, 2020 Jan 16. PMID 31757756, Free PMC Article
    3. RNA methylation by the MIS complex regulates a cell fate decision in yeast. Agarwala SD, et al. PLoS Genet, 2012. PMID 22685417, Free PMC Article
    4. The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks. Davis L, et al. Genetics, 2001 Mar. PMID 11238403, Free PMC Article
    5. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Schwartz S, et al. Cell, 2013 Dec 5. PMID 24269006, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in premeiotic DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mum2p
    NP_009613.1
    • Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      352193..353293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178405.1 → NP_009613.1  TPA: Mum2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009613.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ56, P38236
      UniProtKB/TrEMBL
      A6ZL01, B3LN92, B5VE22, C7GSU3, D3UEF4, G2W962, N1P6H8
      Conserved Domains (1) summary
      pfam17098
      Location:189 → 356
      Wtap; WTAP/Mum2p family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38236.1

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