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    RAD16 DNA repair protein RAD16 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852411, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RAD16
    Gene description
    DNA repair protein RAD16
    Primary source
    FungiDB:YBR114W
    Locus tag
    YBR114W
    See related
    SGD:S000000318; AllianceGenome:SGD:S000000318; VEuPathDB:YBR114W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PSO5
    Summary
    Contributes to ATP-dependent activity, acting on DNA; damaged DNA binding activity; and ubiquitin-protein transferase activity. Involved in cellular protein localization; nucleotide-excision repair, DNA damage recognition; and ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex and nucleotide-excision repair factor 4 complex. Orthologous to human ZRANB3 (zinc finger RANBP2-type containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RAD16 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (467248..469620)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Sus1p Neighboring gene transcription regulator CYC8 Neighboring gene L-aminoadipate-semialdehyde dehydrogenase Neighboring gene transketolase TKL2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Asymmetric repair of UV damage in nucleosomes imposes a DNA strand polarity on somatic mutations in skin cancer. Mao P, et al. Genome Res, 2020 Jan. PMID 31871068, Free PMC Article
    2. Inducible nucleotide excision repair (NER) of UV-induced cyclobutane pyrimidine dimers in the cell cycle of the budding yeast Saccharomyces cerevisiae: evidence that inducible NER is confined to the G1 phase of the mitotic cell cycle. Scott AD, et al. Mol Gen Genet, 1997 Mar 18. PMID 9108289
    3. Isolation and characterization of three mutants with increased sensitivity to photoactivated 3-carbethoxypsoralen in Saccharomyces cerevisiae. Querol CB, et al. Curr Genet, 1994 May. PMID 8082185
    4. Gene PSO5 of Saccharomyces cerevisiae, involved in repair of oxidative DNA damage, is allelic to RAD16. Paesi-Toresan SO, et al. Curr Genet, 1995 May. PMID 7553931
    5. Differential repair of UV damage in rad mutants of Saccharomyces cerevisiae: a possible function of G2 arrest upon UV irradiation. Terleth C, et al. Mol Cell Biol, 1990 Sep. PMID 2201899, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-137 was able to promote sensitivity of PC cells to chemotherapy via inhibition of autophagy mediated by ATG5
      Title: Crystal structure of the yeast Rad7-Elc1 complex and assembly of the Rad7-Rad16-Elc1-Cul3 complex.
    2. use of rad7 Delta rad16 Delta mutants showed that Rad7-Rad16 is required for nucleotide excision repair of UV-lesions in three functionally distinct nucleosome-free regions, the promoter and 3'-end of the URA3 gene and the ARS1 origin of replication
      Title: Functionally distinct nucleosome-free regions in yeast require Rad7 and Rad16 for nucleotide excision repair.
    3. Rad16 mediates the ultraviolet-induced acetylation of histone H3, necessary for efficient global genome nucleotide-excision repair.
      Title: Saccharomyces cerevisiae Rad16 mediates ultraviolet-dependent histone H3 acetylation required for efficient global genome nucleotide-excision repair.
    4. Rad16 is solely responsible for repairing the nontranscribed strand of actively transcribed genes
      Title: The roles of Rad16 and Rad26 in repairing repressed and actively transcribed genes in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ATP-dependent activity, acting on DNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair, DNA damage recognition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide-excision repair, DNA damage recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleotide-excision repair factor 4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein RAD16
    NP_009672.1
    • Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      467248..469620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178462.1 → NP_009672.1  TPA: DNA repair protein RAD16 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009672.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQB3, P31244
      UniProtKB/TrEMBL
      A0A6A5Q165, B3LN39, B5VE76, C7GUL1, D3UEK7, G2W9C0, N1P867
      Conserved Domains (2) summary
      COG0553
      Location:55 → 788
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      COG5432
      Location:537 → 642
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31244.1

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