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    SSH1 Ssh1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852586, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SSH1
    Official Full Name
    Ssh1p
    Primary source
    SGD:S000000487
    Locus tag
    YBR283C
    See related
    AllianceGenome:SGD:S000000487; FungiDB:YBR283C; VEuPathDB:YBR283C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables signal sequence binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Located in endoplasmic reticulum. Part of Ssh1 translocon complex. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SSH1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (768943..770415, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene glutamine amidotransferase subunit DUG2 Neighboring gene mitochondrial 54S ribosomal protein YmL27 Neighboring gene metallo-dependent hydrolase superfamily protein Neighboring gene Hab1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae. Holmstrøm K, et al. Yeast, 1994 Apr. PMID 8091861
    2. The hydrophobic core of the Sec61 translocon defines the hydrophobicity threshold for membrane integration. Junne T, et al. Mol Biol Cell, 2010 May 15. PMID 20357000, Free PMC Article
    3. Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling. Jan CH, et al. Science, 2014 Nov 7. PMID 25378630, Free PMC Article
    4. Mutations in the Sec61p channel affecting signal sequence recognition and membrane protein topology. Junne T, et al. J Biol Chem, 2007 Nov 9. PMID 17893139
    5. Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation. Cheng Z, et al. J Cell Biol, 2005 Jan 3. PMID 15631991, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in SRP-dependent cotranslational protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ssh1 translocon complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ssh1p
    NP_009842.1
    • Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      768943..770415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178631.1 → NP_009842.1  TPA: Ssh1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009842.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQS8, P38353
      UniProtKB/TrEMBL
      A6ZLM1, B3LMN0, C7GMU9, D3UF30, G2W9T6, N1P8N7
      Conserved Domains (1) summary
      PTZ00219
      Location:1 → 472
      PTZ00219; Sec61 alpha subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38353.1

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