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    FRM2 type II nitroreductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850332, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FRM2
    Official Full Name
    type II nitroreductase
    Primary source
    SGD:S000000589
    Locus tag
    YCL026C-A
    See related
    AllianceGenome:SGD:S000000589; FungiDB:YCL026C-A; VEuPathDB:YCL026C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YCLX08C
    Summary
    Enables oxidoreductase activity, acting on NAD(P)H. Involved in cellular response to oxidative stress and negative regulation of fatty acid metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See FRM2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (74704..75285, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Fus1p Neighboring gene putative nitroreductase Neighboring gene amino acid transporter AGP1 Neighboring gene serine/threonine protein kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the fungal nitroreductase Frm2 from Saccharomyces cerevisiae. Song HN, et al. Protein Sci, 2015 Jul. PMID 25864423, Free PMC Article
    2. Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae. Bang SY, et al. Biochem Biophys Res Commun, 2012 Jul 13. PMID 22687599
    3. The role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae. de Oliveira IM, et al. Yeast, 2010 Feb. PMID 19904831
    4. Identification of a class of Saccharomyces cerevisiae mutants defective in fatty acid repression of gene transcription and analysis of the frm2 gene. McHale MW, et al. Yeast, 1996 Mar 30. PMID 8701605
    5. The S. cerevisiae Yap1 and Yap2 transcription factors share a common cadmium-sensing domain. Azevedo D, et al. FEBS Lett, 2007 Jan 23. PMID 17187783

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The study reports the crystal structure of the fungal nitroreductase Frm2 from Saccharomyces cerevisiae.
      Title: Crystal structure of the fungal nitroreductase Frm2 from Saccharomyces cerevisiae.
    2. this study demonstrates a novel nitroreductase activity of Frm2 and its involvement in the oxidative stress defense system.
      Title: Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae.
    3. findings show Frm1p and Hbn1p nitroreductases influence the response to oxidative stress in S. cerevisae by modulating the GSH contents and antioxidant enzymatic activities, such as SOD, CAT & GPx
      Title: The role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    type II nitroreductase
    NP_009904.2
    • Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      74704..75285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178713.1 → NP_009904.2  TPA: type II nitroreductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009904.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQZ0, P37261, Q8NIM8
      UniProtKB/TrEMBL
      A6ZTG4, B3LU56, B5VET3, C7GSY3, C8Z463, G2WA00, N1P990
      Conserved Domains (1) summary
      COG3560
      Location:2 → 193
      FMR2; Fatty acid repression mutant protein (predicted oxidoreductase) [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37261.2

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