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    CWH43 Cwh43p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850376, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CWH43
    Official Full Name
    Cwh43p
    Primary source
    SGD:S000000610
    Locus tag
    YCR017C
    See related
    AllianceGenome:SGD:S000000610; FungiDB:YCR017C; VEuPathDB:YCR017C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in GPI anchor biosynthetic process and fungal-type cell wall organization. Located in cellular bud neck and cellular bud tip. Is integral component of plasma membrane. Orthologous to human CWH43 (cell wall biogenesis 43 C-terminal homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CWH43 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (144773..147634, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene RNA-binding ribosome assembly factor RBP95 Neighboring gene Srd1p Neighboring gene tRNA-Met

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides. Umemura M, et al. Mol Biol Cell, 2007 Nov. PMID 17761529, Free PMC Article
    2. CWH43 is required for the introduction of ceramides into GPI anchors in Saccharomyces cerevisiae. Ghugtyal V, et al. Mol Microbiol, 2007 Sep. PMID 17714445
    3. KNR4, a suppressor of Saccharomyces cerevisiae cwh mutants, is involved in the transcriptional control of chitin synthase genes. Martin H, et al. Microbiology (Reading), 1999 Jan. PMID 10206705
    4. Lipid moiety of glycosylphosphatidylinositol-anchored proteins contributes to the determination of their final destination in yeast. Yoko-O T, et al. Genes Cells, 2018 Oct. PMID 30133879
    5. Determination and physiological roles of the glycosylphosphatidylinositol lipid remodelling pathway in yeast. Yoko-O T, et al. Mol Microbiol, 2013 Apr. PMID 23421703

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in GPI anchor metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cwh43p
    NP_009943.2
    • GPI lipid remodelase; responsible for introducing ceramides into GPI anchors having a C26:0 fatty acid in sn-2 of the glycerol moiety; can also use lyso-GPI protein anchors and various base resistant lipids as substrates; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      144773..147634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178730.1 → NP_009943.2  TPA: Cwh43p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009943.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR25, P25618, Q8NIM1
      UniProtKB/TrEMBL
      C7GT44, C8Z4A4, N1P689
      Conserved Domains (2) summary
      pfam03372
      Location:701 → 911
      Exo_endo_phos; Endonuclease/Exonuclease/phosphatase family
      pfam10277
      Location:5 → 207
      Frag1; Frag1/DRAM/Sfk1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25618.2

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