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    SRB8 Srb8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850442, updated on 6-Oct-2024

    Summary

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    Official Symbol
    SRB8
    Official Full Name
    Srb8p
    Primary source
    SGD:S000000677
    Locus tag
    YCR081W
    See related
    AllianceGenome:SGD:S000000677; FungiDB:YCR081W; VEuPathDB:YCR081W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GIG1; MED12; NUT6; SSN5; YCR080W
    Summary
    Enables transcription coactivator activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and positive regulation of transcription by galactose. Part of mediator complex. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to human MED12 (mediator complex subunit 12) and MED12L (mediator complex subunit 12L). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SRB8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (254371..258654)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Pat1p Neighboring gene type 2C protein phosphatase PTC6 Neighboring gene Ahc2p Neighboring gene Trx3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets. van de Peppel J, et al. Mol Cell, 2005 Aug 19. PMID 16109375
    2. Three subunits of the RNA polymerase II mediator complex are involved in glucose repression. Balciunas D, et al. Nucleic Acids Res, 1995 Nov 11. PMID 7501465, Free PMC Article
    3. Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module. Li YC, et al. Sci Adv, 2021 Jan. PMID 33523904, Free PMC Article
    4. Mediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1p. Thakur JK, et al. J Biol Chem, 2009 Feb 13. PMID 19056732, Free PMC Article
    5. A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast. Borggrefe T, et al. J Biol Chem, 2002 Nov 15. PMID 12200444

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Srb8-Srb11 associates with the GAL1 promoter subsequent to SAGA binding, and the binding of TBP and Srb8-Srb11 is interdependent
      Title: The Saccharomyces cerevisiae Srb8-Srb11 complex functions with the SAGA complex during Gal4-activated transcription.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by galactose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Srb8p
    NP_010004.1
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      254371..258654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178787.1 → NP_010004.1  TPA: Srb8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010004.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR82, P25647, P25648
      UniProtKB/TrEMBL
      G2WA89
      Conserved Domains (1) summary
      pfam09497
      Location:113 → 175
      Med12; Transcription mediator complex subunit Med12
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25648.2

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