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    KIN82 putative serine/threonine protein kinase KIN82 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850453, updated on 29-Jun-2024

    Summary

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    Gene symbol
    KIN82
    Gene description
    putative serine/threonine protein kinase KIN82
    Primary source
    FungiDB:YCR091W
    Locus tag
    YCR091W
    See related
    SGD:S000000687; AllianceGenome:SGD:S000000687; VEuPathDB:YCR091W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FPK2
    Summary
    Enables protein kinase activity. Involved in phospholipid translocation; protein phosphorylation; and response to pheromone triggering conjugation with cellular fusion. Predicted to be active in cytoplasm; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KIN82 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (274404..276566)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Fig2p Neighboring gene uncharacterized protein Neighboring gene mismatch repair protein MSH3 Neighboring gene CCR4-NOT core subunit CDC39

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A putative serine/threonine protein kinase gene on chromosome III of Saccharomyces cerevisiae. Wilson C, et al. Yeast, 1992 Jan. PMID 1580103
    2. Mutations in N-terminal flanking region of blue light-sensing light-oxygen and voltage 2 (LOV2) domain disrupt its repressive activity on kinase domain in the Chlamydomonas phototropin. Aihara Y, et al. J Biol Chem, 2012 Mar 23. PMID 22291022, Free PMC Article
    3. Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Segal E, et al. Nat Genet, 2003 Jun. PMID 12740579
    4. Protein kinases Fpk1p and Fpk2p are novel regulators of phospholipid asymmetry. Nakano K, et al. Mol Biol Cell, 2008 Apr. PMID 18199685, Free PMC Article
    5. An optogenetic system to control membrane phospholipid asymmetry through flippase activation in budding yeast. Suzuki T, et al. Sci Rep, 2020 Jul 27. PMID 32719316, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fpk1 and Fpk2 were involved in two downstream events; that is, ISP-1 uptake due to aminophospholipid flippase and sphingoid long-chain base degradation due to LCB4 expression.
      Title: Fpk1/2 kinases regulate cellular sphingoid long-chain base abundance and alter cellular resistance to LCB elevation or depletion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to pheromone triggering conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative serine/threonine protein kinase KIN82
    NP_010015.3
    • Putative serine/threonine protein kinase; implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases); involved in the phosphorylation of upstream inhibitory kinase Ypk1p along with Fpk1p; has a redundant role in the cellular response to mating pheromone; KIN82 has a paralog, FPK1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      274404..276566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178797.2 → NP_010015.3  TPA: putative serine/threonine protein kinase KIN82 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010015.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR91, P25341
      UniProtKB/TrEMBL
      A0A8H4BUR4, A6ZTR2, B3LUE3
      Conserved Domains (1) summary
      cd05574
      Location:322 → 623
      STKc_phototropin_like; Catalytic domain of Phototropin-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25341.3

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