FAD1 FMN adenylyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: FAD1
Gene description: FMN adenylyltransferase
Primary source: FungiDB:YDL045C
Locus tag: YDL045C
See related: SGD:S000002203; AllianceGenome:SGD:S000002203; VEuPathDB:YDL045C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables FMN adenylyltransferase activity. Involved in FAD biosynthetic process. Located in cytoplasm. Used to study cancer. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FAD1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (372688..373608, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structure of Fad1 shows it to be a member of the PP-ATPase superfamily.
Title: Crystal structure of yeast FAD synthetase (Fad1) in complex with FAD.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables FMN adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables FMN adenylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables FMN adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in FAD biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in FAD biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in FAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in FAD biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FMN adenylyltransferase

NP_010239.1

EC 2.7.7.2

Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

372688..373608 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180104.1 → NP_010239.1 TPA: FMN adenylyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010239.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRV1, P38913

UniProtKB/TrEMBL

A0A8H8UMN6, B3LGU3, B5VFM2, C7GPW4, N1PAA5

Conserved Domains (1) summary

cl00292
Location:55 → 232

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.