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    STP4 Stp4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851512, updated on 18-Sep-2024

    Summary

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    Official Symbol
    STP4
    Official Full Name
    Stp4p
    Primary source
    SGD:S000002206
    Locus tag
    YDL048C
    See related
    AllianceGenome:SGD:S000002206; FungiDB:YDL048C; VEuPathDB:YDL048C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See STP4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (366739..368211, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Lhp1p Neighboring gene Knh1p Neighboring gene type 2A-related serine/threonine-protein phosphatase SIT4 Neighboring gene sterol transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis. Lebesgue N, et al. J Proteome Res, 2017 Feb 3. PMID 28152593
    2. Identifying cooperative transcription factors by combining ChIP-chip data and knockout data. Yang Y, et al. Cell Res, 2010 Nov. PMID 20975739
    3. The external amino acid signaling pathway promotes activation of Stp1 and Uga35/Dal81 transcription factors for induction of the AGP1 gene in Saccharomyces cerevisiae. Abdel-Sater F, et al. Genetics, 2004 Apr. PMID 15126393, Free PMC Article
    4. Sex alters molecular evolution in diploid experimental populations of S. cerevisiae. Leu JY, et al. Nat Ecol Evol, 2020 Mar. PMID 32042122
    5. Analysis of unregulated formin activity reveals how yeast can balance F-actin assembly between different microfilament-based organizations. Gao L, et al. Mol Biol Cell, 2008 Apr. PMID 18234843, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Atg9, Stp4, and Gvp36 are putative new regulators of sphingolipid homeostasis in Saccharomyces cerevisiae.
      Title: Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Stp4p
    NP_010235.1
    • Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has a paralog, STP3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      366739..368211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180107.1 → NP_010235.1  TPA: Stp4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010235.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRU7, P87336, Q05422, Q07351, Q7LGT2, Q7LH06
      UniProtKB/TrEMBL
      A6ZXS6, G2WCB2
      Conserved Domains (2) summary
      COG5048
      Location:14 → 442
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:279 → 296
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07351.2

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