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    SRP14 RNA-binding signal recognition particle subunit SRP14 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851466, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SRP14
    Official Full Name
    RNA-binding signal recognition particle subunit SRP14
    Primary source
    SGD:S000002250
    Locus tag
    YDL092W
    See related
    AllianceGenome:SGD:S000002250; FungiDB:YDL092W; VEuPathDB:YDL092W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 7S RNA binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane, translocation. Part of signal recognition particle, endoplasmic reticulum targeting. Orthologous to human SRP14 (signal recognition particle 14). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SRP14 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (292781..293221)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT1 Neighboring gene putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5 Neighboring gene Ubx3p Neighboring gene protein farnesyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A truncation in the 14 kDa protein of the signal recognition particle leads to tertiary structure changes in the RNA and abolishes the elongation arrest activity of the particle. Thomas Y, et al. Nucleic Acids Res, 1997 May 15. PMID 9115358, Free PMC Article
    2. The Alu domain homolog of the yeast signal recognition particle consists of an Srp14p homodimer and a yeast-specific RNA structure. Strub K, et al. RNA, 1999 Oct. PMID 10573124, Free PMC Article
    3. The sequence of a 16,691 bp segment of Saccharomyces cerevisiae chromosome IV identifies the DUN1, PMT1, PMT5, SRP14 and DPR1 genes, and five new open reading frames. Boskovic J, et al. Yeast, 1996 Oct. PMID 8923743
    4. Engineering protein folding and translocation improves heterologous protein secretion in Saccharomyces cerevisiae. Tang H, et al. Biotechnol Bioeng, 2015 Sep. PMID 25850421
    5. Nuclear export of yeast signal recognition particle lacking Srp54p by the Xpo1p/Crm1p NES-dependent pathway. Ciufo LF, et al. Curr Biol, 2000 Oct 19. PMID 11069106

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 7S RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endoplasmic reticulum signal peptide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal recognition particle, endoplasmic reticulum targeting IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding signal recognition particle subunit SRP14
    NP_010191.1
    • Signal recognition particle (SRP) subunit; interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      292781..293221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180151.1 → NP_010191.1  TPA: RNA-binding signal recognition particle subunit SRP14 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRQ6, P38985
      UniProtKB/TrEMBL
      A6ZXN5, B3LGY7, C7GJM2, G2WC70, N1PA95
      Conserved Domains (1) summary
      pfam02290
      Location:7 → 120
      SRP14; Signal recognition particle 14kD protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38985.1

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