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    MAK21 RNA-binding ribosome biosynthesis protein MAK21 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851632, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MAK21
    Official Full Name
    RNA-binding ribosome biosynthesis protein MAK21
    Primary source
    SGD:S000002467
    Locus tag
    YDR060W
    See related
    AllianceGenome:SGD:S000002467; FungiDB:YDR060W; VEuPathDB:YDR060W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NOC1
    Summary
    Enables mRNA binding activity. Involved in ribosomal large subunit assembly. Located in nucleolus. Part of Noc1p-Noc2p complex. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MAK21 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (570649..573726)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene E2 ubiquitin-conjugating protein UBC5 Neighboring gene uncharacterized protein Neighboring gene serine C-palmitoyltransferase LCB2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The origin of nucleus: rebuild from the prokaryotic ancestors of ribosome export factors. Ohyanagi H, et al. Gene, 2008 Nov 1. PMID 18620034
    2. Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis. Edskes HK, et al. J Biol Chem, 1998 Oct 30. PMID 9786894
    3. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Milkereit P, et al. Cell, 2001 May 18. PMID 11371346
    4. The Noc-domain containing C-terminus of Noc4p mediates both formation of the Noc4p-Nop14p submodule and its incorporation into the SSU processome. Kühn H, et al. PLoS One, 2009 Dec 18. PMID 20019888, Free PMC Article
    5. Rrp5 establishes a checkpoint for 60S assembly during 40S maturation. Khoshnevis S, et al. RNA, 2019 Sep. PMID 31217256, Free PMC Article

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Noc1p-Noc2p complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding ribosome biosynthesis protein MAK21
    NP_010345.3
    • Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      570649..573726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180368.3 → NP_010345.3  TPA: RNA-binding ribosome biosynthesis protein MAK21 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010345.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS46, Q12176
      UniProtKB/TrEMBL
      A6ZY25, C7GVS6, C8Z4X9
      Conserved Domains (1) summary
      COG5593
      Location:173 → 1022
      COG5593; Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12176.1

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