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    KGD2 dihydrolipoyl transsuccinylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851726, updated on 9-Jun-2024

    Summary

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    Gene symbol
    KGD2
    Gene description
    dihydrolipoyl transsuccinylase
    Primary source
    FungiDB:YDR148C
    Locus tag
    YDR148C
    See related
    SGD:S000002555; AllianceGenome:SGD:S000002555; VEuPathDB:YDR148C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable dihydrolipoyllysine-residue succinyltransferase activity. Involved in 2-oxoglutarate metabolic process. Located in mitochondrial nucleoid. Part of mitochondrial oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KGD2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (753675..755066, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA-binding transcription factor SWI5 Neighboring gene bifunctional choline kinase/ethanolamine kinase EKI1 Neighboring gene Num1p Neighboring gene putative mRNA-binding protein CTH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and regulation of KGD2, the structural gene for yeast dihydrolipoyl transsuccinylase. Repetto B, et al. Mol Cell Biol, 1990 Aug. PMID 2115121, Free PMC Article
    2. In vivo assembly of yeast mitochondrial alpha-ketoglutarate dehydrogenase complex. Repetto B, et al. Mol Cell Biol, 1991 Aug. PMID 2072900, Free PMC Article
    3. Conservation of Transit Peptide-Independent Protein Import into the Mitochondrial and Hydrogenosomal Matrix. Garg S, et al. Genome Biol Evol, 2015 Sep 2. PMID 26338186, Free PMC Article
    4. Identification of the YMN-1 antigen protein and biochemical analyses of protein components in the mitochondrial nucleoid fraction of the yeast Saccharomyces cerevisiae. Sato H, et al. Protoplasma, 2002 Feb. PMID 11926067
    5. The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase. Heublein M, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165143, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydrolipoyllysine-residue succinyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydrolipoyllysine-residue succinyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydrolipoyllysine-residue succinyltransferase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oxoglutarate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dihydrolipoyl transsuccinylase
    NP_010432.3
    • Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      753675..755066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180455.3 → NP_010432.3  TPA: dihydrolipoyl transsuccinylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010432.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSD1, P19262
      UniProtKB/TrEMBL
      A0A6A5Q2A4, B3LGD2, C7GIQ3, C8Z564, G2WAP8, N1P4T9
      Conserved Domains (1) summary
      TIGR01347
      Location:74 → 463
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19262.2

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