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    CDC37 Cdc37p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851746, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CDC37
    Official Full Name
    Cdc37p
    Primary source
    SGD:S000002575
    Locus tag
    YDR168W
    See related
    AllianceGenome:SGD:S000002575; FungiDB:YDR168W; VEuPathDB:YDR168W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SMO1
    Summary
    Enables unfolded protein binding activity. Involved in several processes, including p38MAPK cascade; protein stabilization; and spindle pole body duplication. Located in cytoplasm. Orthologous to human CDC37L1 (cell division cycle 37 like 1, HSP90 cochaperone) and CDC37 (cell division cycle 37, HSP90 cochaperone). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CDC37 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (790328..791848)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene exocyst subunit SEC5 Neighboring gene Taf10p Neighboring gene Stb3p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential in vivo regulation of steroid hormone receptor activation by Cdc37p. Fliss AE, et al. Mol Biol Cell, 1997 Dec. PMID 9398671, Free PMC Article
    2. Candida albicans Cdc37 interacts with the Crk1 kinase and is required for Crk1 production. Ni J, et al. FEBS Lett, 2004 Mar 12. PMID 15013782
    3. The yeast CDC37 gene interacts with MPS1 and is required for proper execution of spindle pole body duplication. Schutz AR, et al. J Cell Biol, 1997 Mar 10. PMID 9060463, Free PMC Article
    4. Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins. Gerber MR, et al. Proc Natl Acad Sci U S A, 1995 May 9. PMID 7753858, Free PMC Article
    5. The selection of amber mutations in genes required for completion of start, the controlling event of the cell division cycle of S. cerevisiae. Reed SI. Genetics, 1980 Jul. PMID 7002719, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. unusual stability of this Cak1:Cdc37 association may partly reflect unique structural features of the fungal Cak1
      Title: Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1).
    2. Studies propose that Sic1, Cdc37, and Hsp82 may orchestrate parts of the cellular starvation response by regulating transcription factor- and kinase activities.
      Title: Quantitative proteomics identifies unanticipated regulators of nitrogen- and glucose starvation.
    3. Kss1p interacts physically with Cdc37p
      Title: Cdc37p is involved in osmoadaptation and controls high osmolarity-induced cross-talk via the MAP kinase Kss1p.
    4. Cdc37p is a part of chaperone system that determins molybdate resistance in Saccharomyces cerevisiae.
      Title: The Hsp90/Cdc37p chaperone system is a determinant of molybdate resistance in Saccharomyces cerevisiae.
    5. There are at least 38 genes having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37.
      Title: Multiple kinases and system robustness: a link between Cdc37 and genome integrity.
    6. During cell wall stress, the interaction between Cdc37p, Hog1p, and Hsp90 is crucial for Slt2p-dependent downstream responses to high osmotic and cell wall stress, respectively.
      Title: Cdc37p is required for stress-induced high-osmolarity glycerol and protein kinase C mitogen-activated protein kinase pathway functionality by interaction with Hog1p and Slt2p (Mpk1p).
    7. Cdc37 has a general role in kinome biogenesis
      Title: Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular hyperosmotic response IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization or biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in p38MAPK cascade IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle pole body duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cdc37p
    NP_010452.1
    • Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      790328..791848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180475.1 → NP_010452.1  TPA: Cdc37p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010452.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSE8, P06101, Q04132
      UniProtKB/TrEMBL
      A6ZYC6, B3LGB6, B5VG63, C7GQF1, C8Z581, G2WAR6, N1P8B5
      Conserved Domains (3) summary
      smart01071
      Location:2 → 183
      CDC37_N; Cdc37 N terminal kinase binding
      smart01069
      Location:389 → 490
      CDC37_C; Cdc37 C terminal domain
      smart01070
      Location:207 → 368
      CDC37_M; Cdc37 Hsp90 binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06101.2

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