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    PAC2 Pac2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856724, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PAC2
    Official Full Name
    Pac2p
    Primary source
    SGD:S000000809
    Locus tag
    YER007W
    See related
    AllianceGenome:SGD:S000000809; FungiDB:YER007W; VEuPathDB:YER007W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-tubulin binding activity. Involved in protein folding and tubulin complex assembly. Predicted to be located in microtubule. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Kenny-Caffey syndrome type 1; hypoparathyroidism; and hypoparathyroidism-retardation-dysmorphism syndrome. Orthologous to several human genes including TBCE (tubulin folding cofactor E). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PAC2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (164527..166083)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene apyrase Neighboring gene RNA-binding GTPase NUG1 Neighboring gene translation machinery-associated protein 20 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. Nithianantham S, et al. Elife, 2015 Jul 24. PMID 26208336, Free PMC Article
    2. A method for efficient quantitative analysis of genomic subtelomere Y' element abundance in yeasts. Liu J, et al. Yeast, 2020 Jul. PMID 32639041
    3. Function of tubulin binding proteins in vivo. Fleming JA, et al. Genetics, 2000 Sep. PMID 10978276, Free PMC Article
    4. Saccharomyces cerevisiae PAC2 functions with CIN1, 2 and 4 in a pathway leading to normal microtubule stability. Hoyt MA, et al. Genetics, 1997 Jul. PMID 9215891, Free PMC Article
    5. An alpha-tubulin mutant destabilizes the heterodimer: phenotypic consequences and interactions with tubulin-binding proteins. Vega LR, et al. Mol Biol Cell, 1998 Sep. PMID 9725898, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-tubulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-chaperonin tubulin folding pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tubulin complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tubulin complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pac2p
    NP_010922.1
    • Microtubule effector required for tubulin heterodimer formation; binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      164527..166083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178898.1 → NP_010922.1  TPA: Pac2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010922.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLQ3, P39937
      UniProtKB/TrEMBL
      A6ZQV3, B5VHD8, C8Z706, G2WCN7, N1P3W8
      Conserved Domains (4) summary
      smart01052
      Location:5 → 72
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      sd00033
      Location:154 → 179
      LRR_RI; leucine-rich repeat [structural motif]
      cl28922
      Location:445 → 502
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
      cl39015
      Location:175 → 350
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39937.1

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