ARG56 bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ARG56
Official Full Name: bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase
Primary source: SGD:S000000871
Locus tag: YER069W
See related: AllianceGenome:SGD:S000000871; FungiDB:YER069W; VEuPathDB:YER069W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables N-acetyl-gamma-glutamyl-phosphate reductase activity and acetylglutamate kinase activity. Involved in regulation of transcription, DNA-templated. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in N-acetylglutamate synthase deficiency and amino acid metabolic disorder. Orthologous to human NAGS (N-acetylglutamate synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ARG56 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (295410..298001)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

associated with specific nuclear and mitochondrial loci in vivo; binds to specific fragments in vitro; deletion of Arg5,6 causes altered transcript levels of both nuclear and mitochondrial target genes
Title: Regulation of gene expression by a metabolic enzyme.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables N-acetyl-gamma-glutamyl-phosphate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyl-gamma-glutamyl-phosphate reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetyl-gamma-glutamyl-phosphate reductase activity	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP+ binding	IEA Inferred from Electronic Annotation more info
enables acetylglutamate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylglutamate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylglutamate kinase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-arginine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-arginine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-arginine biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in alpha-amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ornithine biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase

NP_010992.1

EC 1.2.1.38

EC 2.7.2.8

Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

295410..298001

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178960.1 → NP_010992.1 TPA: bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010992.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLX4, Q01217

UniProtKB/TrEMBL

A6ZR23, B3LRI6, B5VHJ9, C7GRQ1, C8Z777, N1P3E7

Conserved Domains (3) summary

cd04252
Location:100 → 348

AAK_NAGK-fArgBP; N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-terminal reductase domain ...

TIGR01850
Location:542 → 856

argC; N-acetyl-gamma-glutamyl-phosphate reductase, common form

pfam04768
Location:333 → 499

NAT; N-acetyltransferase, of N-acetylglutamate synthase