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    RPL11B ribosomal 60S subunit protein L11B [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852976, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RPL11B
    Gene description
    ribosomal 60S subunit protein L11B
    Primary source
    FungiDB:YGR085C
    Locus tag
    YGR085C
    See related
    SGD:S000003317; AllianceGenome:SGD:S000003317; VEuPathDB:YGR085C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Involved in ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 7 and T-cell acute lymphoblastic leukemia. Orthologous to human RPL11 (ribosomal protein L11). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPL11B in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (648383..648907, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF2B subunit delta Neighboring gene mitochondrial 37S ribosomal protein YmS-A Neighboring gene lipid-binding protein PIL1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization of Saccharomyces cerevisiae ribosomal protein L16 on the surface of 60 S ribosomal subunits by immunoelectron microscopy. Tsay YF, et al. J Biol Chem, 1994 Mar 11. PMID 7510288
    2. A flexible loop in yeast ribosomal protein L11 coordinates P-site tRNA binding. Rhodin MH, et al. Nucleic Acids Res, 2010 Dec. PMID 20705654, Free PMC Article
    3. Nutrient availability and the RAS/cyclic AMP pathway both induce expression of ribosomal protein genes in Saccharomyces cerevisiae but by different mechanisms. Neuman-Silberberg FS, et al. Mol Cell Biol, 1995 Jun. PMID 7760815, Free PMC Article
    4. Ribosomal protein synthesis is not regulated at the translational level in Saccharomyces cerevisiae: balanced accumulation of ribosomal proteins L16 and rp59 is mediated by turnover of excess protein. Tsay YF, et al. Genes Dev, 1988 Jun. PMID 3047007
    5. Functional analysis of the uL11 protein impact on translational machinery. Wawiórka L, et al. Cell Cycle, 2016. PMID 26939941, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L11B
    NP_011599.1
    • Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      648383..648907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181214.1 → NP_011599.1  TPA: ribosomal 60S subunit protein L11B [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUL7, Q3E757
      UniProtKB/TrEMBL
      A0A6A5PYM2, A6ZV67, B3LIE1, B5VJ29, C8Z8X9, G2WEG9, N1P3L3
      Conserved Domains (1) summary
      PTZ00156
      Location:2 → 172
      PTZ00156; 60S ribosomal protein L11; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E757.3

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