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    ASN2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853025, updated on 22-Aug-2024

    Summary

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    Official Symbol
    ASN2
    Primary source
    FungiDB:YGR124W
    Locus tag
    YGR124W
    See related
    SGD:S000003356; AllianceGenome:SGD:S000003356; VEuPathDB:YGR124W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables asparagine synthase (glutamine-hydrolyzing) activity. Involved in asparagine biosynthetic process. Located in cytoplasm. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (739944..741662)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene protein serine/threonine phosphatase Neighboring gene tRNA-Ile Neighboring gene Vsb1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae ASN1 and ASN2 are asparagine synthetase paralogs that have diverged in their ability to polymerize in response to nutrient stress. Noree C, et al. Sci Rep, 2019 Jan 22. PMID 30670751, Free PMC Article
    2. Human asparagine synthetase associates with the mitotic spindle. Noree C, et al. Biol Open, 2018 Dec 14. PMID 30464009, Free PMC Article
    3. Filamentation of asparagine synthetase in Saccharomyces cerevisiae. Zhang S, et al. PLoS Genet, 2018 Oct. PMID 30365499, Free PMC Article
    4. Two asparagine synthetases in Saccharomyces cerevisiae. Ramos F, et al. Eur J Biochem, 1980 Jul. PMID 6105958
    5. ASNS disruption shortens CTPS cytoophidia in Saccharomyces cerevisiae. Zhang S, et al. G3 (Bethesda), 2021 Jan 18. PMID 33561249, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear targeted Saccharomyces cerevisiae asparagine synthetases associate with the mitotic spindle regardless of their enzymatic activity.
      Title: Nuclear targeted Saccharomyces cerevisiae asparagine synthetases associate with the mitotic spindle regardless of their enzymatic activity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables asparagine synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-asparagine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asparagine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparagine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asparagine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    asparagine synthase (glutamine-hydrolyzing) 2
    NP_011640.1
    • Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      739944..741662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181253.1 → NP_011640.1  TPA: asparagine synthase (glutamine-hydrolyzing) 2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011640.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUQ6, E9P8Y0, P49090
      UniProtKB/TrEMBL
      A6ZUD8, B3LIA4, C7GUH1, C8Z917, G2WEK6, N1P2B6
      Conserved Domains (1) summary
      PRK09431
      Location:1 → 561
      asnB; asparagine synthetase B; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49090.2

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