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    GPC1 glycerophosphocholine acyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853052, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPC1
    Official Full Name
    glycerophosphocholine acyltransferase
    Primary source
    SGD:S000003381
    Locus tag
    YGR149W
    See related
    AllianceGenome:SGD:S000003381; FungiDB:YGR149W; VEuPathDB:YGR149W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glycero-3-phosphocholine acyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Acts upstream of or within phosphatidylcholine acyl-chain remodeling and phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine. Located in cell periphery and endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GPC1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (789031..790329)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Nat2p Neighboring gene ribosomal 60S subunit protein L24B Neighboring gene Ccm1p Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The acyltransferase Gpc1 is both a target and an effector of the unfolded protein response in Saccharomyces cerevisiae. Hrach VL, et al. J Biol Chem, 2023 Jul. PMID 37269946, Free PMC Article
    2. Cloning of Glycerophosphocholine Acyltransferase (GPCAT) from Fungi and Plants: A NOVEL ENZYME IN PHOSPHATIDYLCHOLINE SYNTHESIS. Głąb B, et al. J Biol Chem, 2016 Nov 25. PMID 27758859, Free PMC Article
    3. The glycerophosphocholine acyltransferase Gpc1 is part of a phosphatidylcholine (PC)-remodeling pathway that alters PC species in yeast. Anaokar S, et al. J Biol Chem, 2019 Jan 25. PMID 30514764, Free PMC Article
    4. Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions. Kim H, et al. J Biol Chem, 2003 Mar 21. PMID 12524434
    5. Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis. Opaliński Ł, et al. Cell Rep, 2018 Nov 20. PMID 30463002, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycero-3-phosphocholine acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycero-3-phosphocholine acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphatidylcholine acyl-chain remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycerophosphocholine acyltransferase
    NP_011665.1
    • Glycerophosphocholine acyltransferase (GPCAT); involved in in phosphatidylcholine (PC) synthesis; uses acyl-CoA to acylate glycero-3-phosphocholine to yield lyso-PC; also catalyzes acylation of glycerophosphoethanolamine with acyl-CoA; predicted to be an integral membrane protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      789031..790329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181278.1 → NP_011665.1  TPA: glycerophosphocholine acyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011665.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUT0, P48236
      UniProtKB/TrEMBL
      A6ZUG1, B3LI80, B5VJ92, C7GQ58, C8Z943, G2WEN0, N1P5Y5
      Conserved Domains (1) summary
      pfam10998
      Location:115 → 221
      DUF2838; Protein of unknown function (DUF2838)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48236.1

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