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    SLI1 N-acetyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853126, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SLI1
    Official Full Name
    N-acetyltransferase
    Primary source
    SGD:S000003444
    Locus tag
    YGR212W
    See related
    AllianceGenome:SGD:S000003444; FungiDB:YGR212W; VEuPathDB:YGR212W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables N-acetyltransferase activity. Involved in response to xenobiotic stimulus. Is active in nuclear envelope and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SLI1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (917040..918446)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene zinc finger-containing protein ZPR1 Neighboring gene Rta1p Neighboring gene ribosomal 40S subunit protein S0A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast. Momoi M, et al. Biochem J, 2004 Jul 1. PMID 15025559, Free PMC Article
    2. Combinatorial gene overexpression and recessive mutant gene introduction in sake yeast. Ano A, et al. Biosci Biotechnol Biochem, 2009 Mar 23. PMID 19270382
    3. Genome-Wide Studies of Rho5-Interacting Proteins That Are Involved in Oxidant-Induced Cell Death in Budding Yeast. Singh K, et al. G3 (Bethesda), 2019 Mar 7. PMID 30670610, Free PMC Article
    4. Misregulation of cell cycle-dependent methylation of budding yeast CENP-A contributes to chromosomal instability. Mishra PK, et al. Mol Biol Cell, 2023 Sep 1. PMID 37436802, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Tettelin H, et al. Nature, 1997 May 29. PMID 9169869

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetyltransferase
    NP_011728.3
    • N-acetyltransferase; confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      917040..918446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181341.3 → NP_011728.3  TPA: N-acetyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011728.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUZ5, P53304
      UniProtKB/TrEMBL
      A6ZUM3, N1P4B0
      Conserved Domains (1) summary
      cl23853
      Location:4 → 447
      Condensation; Condensation domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53304.1

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