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    GRE3 trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856504, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GRE3
    Official Full Name
    trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))
    Primary source
    SGD:S000001146
    Locus tag
    YHR104W
    See related
    AllianceGenome:SGD:S000001146; FungiDB:YHR104W; VEuPathDB:YHR104W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-xylose:NADP reductase activity and mRNA binding activity. Involved in cellular response to osmotic stress; cellular response to oxidative stress; and monosaccharide catabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal 8; congenital bile acid synthesis defect 2; diabetic neuropathy; leukemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GRE3 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (323409..324392)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene putative serine/threonine protein kinase KIC1 Neighboring gene Sbe22p Neighboring gene Ypt35p Neighboring gene thioredoxin-disulfide reductase TRR2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploiting the NADPH pool for xylitol production using recombinant Saccharomyces cerevisiae. Reshamwala SMS, et al. Biotechnol Prog, 2020 May. PMID 31990139
    2. Engineering and two-stage evolution of a lignocellulosic hydrolysate-tolerant Saccharomyces cerevisiae strain for anaerobic fermentation of xylose from AFEX pretreated corn stover. Parreiras LS, et al. PLoS One, 2014. PMID 25222864, Free PMC Article
    3. Feasibility of xylose fermentation by engineered Saccharomyces cerevisiae overexpressing endogenous aldose reductase (GRE3), xylitol dehydrogenase (XYL2), and xylulokinase (XYL3) from Scheffersomyces stipitis. Kim SR, et al. FEMS Yeast Res, 2013 May. PMID 23398717
    4. Investigation of the role of a conserved glycine motif in the Saccharomyces cerevisiae xylose reductase. Chu BC, et al. Curr Microbiol, 2006 Aug. PMID 16802208
    5. Endogenous NADPH-dependent aldose reductase activity influences product formation during xylose consumption in recombinant Saccharomyces cerevisiae. Träff-Bjerre KL, et al. Yeast, 2004 Jan 30. PMID 14755639

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-xylose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-xylose reductase (NADPH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-xylose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-xylose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in arabinose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arabinose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in galactose catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))
    NP_011972.1
    • Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by HOG pathway; overexpression allows xylose fermentation in strains expressing heterologous xylitol dehydrogenase and xylulokinase; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      323409..324392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179234.1 → NP_011972.1  TPA: trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011972.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL54, P38715
      UniProtKB/TrEMBL
      A0A2S0UVX7, A6ZT12, B5VK39, C7GLZ0, C8Z9P7, G2WFH8, N1P141
      Conserved Domains (1) summary
      cl00470
      Location:3 → 318
      AKR_SF; Aldo-keto reductase (AKR) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38715.1

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