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    NVJ1 Nvj1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856602, updated on 3-Nov-2024

    Summary

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    Official Symbol
    NVJ1
    Official Full Name
    Nvj1p
    Primary source
    SGD:S000001238
    Locus tag
    YHR195W
    See related
    AllianceGenome:SGD:S000001238; FungiDB:YHR195W; VEuPathDB:YHR195W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VAB36
    Summary
    Enables structural molecule activity. Involved in nucleus-vacuole junction assembly; piecemeal microautophagy of the nucleus; and protein localization. Located in membrane and nuclear envelope. Is active in nucleus-vacuole junction. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See NVJ1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (490747..491712)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Egd2p Neighboring gene Mdm31p Neighboring gene Utp9p Neighboring gene Rix1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interorganelle interactions and inheritance patterns of nuclei and vacuoles in budding yeast meiosis. Tsai IT, et al. Autophagy, 2014 Feb. PMID 24345927, Free PMC Article
    2. The luminal N-terminus of yeast Nvj1 is an inner nuclear membrane anchor. Millen JI, et al. Traffic, 2008 Sep. PMID 18694438, Free PMC Article
    3. Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways. Park J, et al. Autophagy, 2020 Jun. PMID 31512555, Free PMC Article
    4. Structure and function of nucleus-vacuole junctions: outer-nuclear-membrane targeting of Nvj1p and a role in tryptophan uptake. Kvam E, et al. J Cell Sci, 2006 Sep 1. PMID 16912077
    5. Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae. Roberts P, et al. Mol Biol Cell, 2003 Jan. PMID 12529432, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Report the crystal structure of Vac8p bound to Nvj1p at 2.4-A resolution. Vac8p comprises a flexibly connected N-terminal H1 helix followed by 12 armadillo repeats (ARMs) that form a right-handed superhelical structure. The extended 80-A-long loop of Nvj1p specifically binds the highly conserved inner groove formed from ARM1-12 of Vac8p.
      Title: Mechanistic insight into the nucleus-vacuole junction based on the Vac8p-Nvj1p crystal structure.
    2. Results present a map of the domains of Nvj1p responsible for outer nuclear membrane targeting and partner binding.
      Title: Structure and function of nucleus-vacuole junctions: outer-nuclear-membrane targeting of Nvj1p and a role in tryptophan uptake.
    3. Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae
      Title: Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding protein homolog Osh1p in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleus-vacuole junction assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleus-vacuole junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus-vacuole junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus-vacuole junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nvj1p
    NP_012065.3
    • Nuclear envelope protein; anchored to nuclear inner membrane, interacts with vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN); targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      490747..491712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179326.3 → NP_012065.3  TPA: Nvj1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012065.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLE3, P38881
      UniProtKB/TrEMBL
      C8Z9Z5, N1P4X0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38881.1

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