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    AIM18 Aim18p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856605, updated on 2-Nov-2024

    Summary

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    Official Symbol
    AIM18
    Official Full Name
    Aim18p
    Primary source
    SGD:S000001241
    Locus tag
    YHR198C
    See related
    AllianceGenome:SGD:S000001241; FungiDB:YHR198C; VEuPathDB:YHR198C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FMP22
    Summary
    Enables heme binding activity. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See AIM18 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (496315..497280, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Utp9p Neighboring gene Rix1p Neighboring gene Aim46p Neighboring gene borealin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae. Schmitz JM, et al. J Biol Chem, 2023 Mar. PMID 36739946, Free PMC Article
    2. Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling. Stefely JA, et al. Nat Biotechnol, 2016 Nov. PMID 27669165, Free PMC Article
    3. Elucidation of the interaction proteome of mitochondrial chaperone Hsp78 highlights its role in protein aggregation during heat stress. Jaworek W, et al. J Biol Chem, 2022 Oct. PMID 36115461, Free PMC Article
    4. Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. Hess DC, et al. PLoS Genet, 2009 Mar. PMID 19300474, Free PMC Article
    5. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Johnston M, et al. Science, 1994 Sep 30. PMID 8091229

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.
      Title: Aim18p and Aim46p are chalcone isomerase domain-containing mitochondrial hemoproteins in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables intramolecular lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aim18p
    NP_012068.1
    • Hemoprotein; hypothetical protein that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      496315..497280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179329.1 → NP_012068.1  TPA: Aim18p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012068.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZTA4, B3LSV8, B5VKC6, C8Z9Z8, D3DLE6, P38884
      UniProtKB/TrEMBL
      G2WFS1, N1P9I7
      Conserved Domains (1) summary
      pfam16035
      Location:113 → 311
      Chalcone_2; Chalcone isomerase like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38884.1

    Gene LinkOut

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