U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NAS2 Nas2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854810, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    NAS2
    Gene description
    Nas2p
    Primary source
    FungiDB:YIL007C
    Locus tag
    YIL007C
    See related
    SGD:S000001269; AllianceGenome:SGD:S000001269; VEuPathDB:YIL007C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in proteasome regulatory particle assembly. Located in cytosol and nucleus. Orthologous to human PSMD9 (proteasome 26S subunit, non-ATPase 9). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NAS2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (342994..343656, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene long-chain fatty acid-CoA ligase FAA3 Neighboring gene ubiquitin-related modifier URM1 Neighboring gene NAD+ transporter Neighboring gene protein disulfide isomerase EPS1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. 1.15 Å resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain. Singh CR, et al. Acta Crystallogr F Struct Biol Commun, 2014 Apr. PMID 24699731, Free PMC Article
    2. cDNA cloning and characterization of a human proteasomal modulator subunit, p27 (PSMD9). Watanabe TK, et al. Genomics, 1998 Jun 1. PMID 9653651
    3. Tagging the proteasome active site β5 causes tag specific phenotypes in yeast. Waite KA, et al. Sci Rep, 2020 Oct 22. PMID 33093623, Free PMC Article
    4. Mitochondria-Associated Degradation Pathway (MAD) Function beyond the Outer Membrane. Liao PC, et al. Cell Rep, 2020 Jul 14. PMID 32668258, Free PMC Article
    5. Two alternative mechanisms regulate the onset of chaperone-mediated assembly of the proteasomal ATPases. Nahar A, et al. J Biol Chem, 2019 Apr 19. PMID 30814255, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein.
      Title: Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome regulatory particle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome regulatory particle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome regulatory particle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome regulatory particle assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteasome regulatory particle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Nas2p
    NP_012259.3
    • Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress; ortholog of human p27

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      342994..343656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179357.3 → NP_012259.3  TPA: Nas2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012259.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVS3, P40555
      UniProtKB/TrEMBL
      A0A8H4BZ97, A6ZVR1, B3LTL6, B5VKT0, C7GJH8, G2WGD9, N1P294
      Conserved Domains (2) summary
      pfam00595
      Location:106 → 182
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam18265
      Location:31 → 109
      Nas2_N; Nas2 N_terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40555.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous