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    ICE2 Ice2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854718, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ICE2
    Official Full Name
    Ice2p
    Primary source
    SGD:S000001352
    Locus tag
    YIL090W
    See related
    AllianceGenome:SGD:S000001352; FungiDB:YIL090W; VEuPathDB:YIL090W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including endoplasmic reticulum organization; protein localization to membrane; and septin ring assembly. Located in endoplasmic reticulum membrane and perinuclear endoplasmic reticulum. Is active in cortical endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ICE2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (193595..195070)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene rRNA-binding ribosome biosynthesis protein UTP25 Neighboring gene uncharacterized protein Neighboring gene tRNA-Glu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide functional profiling identifies genes and processes important for zinc-limited growth of Saccharomyces cerevisiae. North M, et al. PLoS Genet, 2012. PMID 22685415, Free PMC Article
    2. Over-expression of ICE2 stabilizes cytochrome P450 reductase in Saccharomyces cerevisiae and Pichia pastoris. Emmerstorfer A, et al. Biotechnol J, 2015 Apr. PMID 25641738
    3. Ice2p is important for the distribution and structure of the cortical ER network in Saccharomyces cerevisiae. Estrada de Martin P, et al. J Cell Sci, 2005 Jan 1. PMID 15585575
    4. Fungal Ice2p is in the same superfamily as SERINCs, restriction factors for HIV and other viruses. Alli-Balogun GO, et al. Proteins, 2021 Oct. PMID 33982326
    5. An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER. Markgraf DF, et al. Cell Rep, 2014 Jan 16. PMID 24373967, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex.
      Title: Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex.
    2. Ice2p interacts with lipid droplets and promotes triacylglycerol utilization for phospholipid synthesis.
      Title: An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein serine/threonine phosphatase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum inheritance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum membrane biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endoplasmic reticulum membrane biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-translational protein targeting to membrane, translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to nuclear inner membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septin ring assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in septin ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cortical endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ice2p
    NP_012176.1
    • Integral ER membrane protein with type-III transmembrane domains; promotes ER membrane expansion by inhibiting the Nem1-Spo7 phosphatase complex, resulting in reduced dephosphorylation and activation of Pah1p; maintains homeostasis during ER stress; required for post-translational SRP-independent protein translocation into the ER; necessary for efficient targeting of the Trm1p to the inner nuclear membrane; mutations cause defects in cortical ER morphology; member of the SERINC superfamily

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      193595..195070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179438.1 → NP_012176.1  TPA: Ice2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012176.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVJ7, P40499, Q6B2T7
      UniProtKB/TrEMBL
      A6ZVI7, B3LTT7, B5VKL7, C7GKL7, C8ZAF9, N1P9B8
      Conserved Domains (1) summary
      pfam08426
      Location:14 → 488
      ICE2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40499.1

    Gene LinkOut

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