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    GWT1 glucosaminyl-phosphotidylinositol O-acyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853354, updated on 29-Jun-2024

    Summary

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    Gene symbol
    GWT1
    Gene description
    glucosaminyl-phosphotidylinositol O-acyltransferase
    Primary source
    FungiDB:YJL091C
    Locus tag
    YJL091C
    See related
    SGD:S000003627; AllianceGenome:SGD:S000003627; VEuPathDB:YJL091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glucosaminyl-phosphatidylinositol O-acyltransferase activity. Involved in GPI anchor biosynthetic process. Is integral component of membrane. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GWT1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (261080..262552, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tok1p Neighboring gene DNA helicase SRS2 Neighboring gene protein kinase activating protein DPB11 Neighboring gene Sip4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly. Tsukahara K, et al. Mol Microbiol, 2003 May. PMID 12753194
    2. Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis. Mann PA, et al. ACS Infect Dis, 2015 Jan 9. PMID 26878058, Free PMC Article
    3. Analysis of membrane topology and identification of essential residues for the yeast endoplasmic reticulum inositol acyltransferase Gwt1p. Sagane K, et al. J Biol Chem, 2011 Apr 22. PMID 21367863, Free PMC Article
    4. GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast. Umemura M, et al. J Biol Chem, 2003 Jun 27. PMID 12714589
    5. Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site. Miosga T, et al. Yeast, 1995 Jun 15. PMID 7483841

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of essential residues of PIG-W and Gwt1p and membrane topology of Gwt1p
      Title: Analysis of membrane topology and identification of essential residues for the yeast endoplasmic reticulum inositol acyltransferase Gwt1p.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucosaminyl-phosphatidylinositol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosaminyl-phosphatidylinositol O-acyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glucosaminyl-phosphatidylinositol O-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear outer membrane-endoplasmic reticulum membrane network HDA PubMed 

    General protein information

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    Preferred Names
    glucosaminyl-phosphotidylinositol O-acyltransferase
    NP_012444.2
    • Protein involved in the inositol acylation of GlcN-PI; the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) forms glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      261080..262552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181524.1 → NP_012444.2  TPA: glucosaminyl-phosphotidylinositol O-acyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012444.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW93, P47026
      UniProtKB/TrEMBL
      A0A8H4FC54, B3LQ22, C7GR23, N1P186
      Conserved Domains (1) summary
      cl02109
      Location:4 → 490
      GWT1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47026.2

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