IME2 protein kinase IME2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IME2
Official Full Name: protein kinase IME2
Primary source: SGD:S000003642
Locus tag: YJL106W
See related: AllianceGenome:SGD:S000003642; FungiDB:YJL106W; VEuPathDB:YJL106W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SME1
Summary: Enables protein kinase activity. Involved in regulation of meiotic nuclear division. Located in nucleus. Human ortholog(s) of this gene implicated in endocrine-cerebro-osteodysplasia syndrome; juvenile myoclonic epilepsy 10; and retinitis pigmentosa 62. Orthologous to several human genes including CILK1 (ciliogenesis associated kinase 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See IME2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (221390..223327)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identify the protein kinase Ime2 to bring about Rim4 clearance via phosphorylation of Rim4's intrinsically disordered region
Title: Phosphorylation-Mediated Clearance of Amyloid-like Assemblies in Meiosis.
Here we show that Ime2 activity is required to induce the translation of SSP2 mRNA at anaphase II
Title: Autophosphorylation of the Smk1 MAPK is spatially and temporally regulated by Ssp2 during meiotic development in yeast.
Positive auto-regulation of Ime2 produces a bistable system with a normal meiotic state and a more efficient meiotic state.
Title: Dynamic modeling of yeast meiotic initiation.
Ime2 does not directly catalyze Sic1 phosphorylation to target it for destabilization as Cln1,-2/Cdk1 do during the cell cycle
Title: Yeast IME2 functions early in meiosis upstream of cell cycle-regulated SBF and MBF targets.
The ectope expression of Ime2 has deterious on cell cycle regulation, toxocity and the response of the DNA damage checkpoint.
Title: Ectopic expression of human Cdk2 and its yeast homolog, Ime2, is deleterious to Saccharomyces cerevisiae.
Epistasis analysis suggests that Ime1 and Ime2 act in the same order in pseudohyphal growth as in meiosis.
Title: Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on nonfermentable carbon sources.
Data show that the Sum1 repressor can be removed from middle promoters in meiotic cells independent of Ndt80 expression, and that this process requires the phosphorylation of Sum1 by Ime2.
Title: The Ime2 protein kinase enhances the disassociation of the Sum1 repressor from middle meiotic promoters.
Ime2 is a key activator of Smk1 signaling.
Title: The Ras/cAMP pathway and the CDK-like kinase Ime2 regulate the MAPK Smk1 and spore morphogenesis in Saccharomyces cerevisiae.
Results show that human Cdk2 is a functional homolog for most of Ime2 functions.
Title: Human Cdk2 is a functional homolog of budding yeast Ime2, the meiosis-specific Cdk-like kinase.
The glucose sensors had only a minor role in regulating transcript levels of the two key regulators of meiotic initiation, the Ime1p transcription factor and the Ime2p kinase, but a major role in regulating Ime2p stability.
Title: Glucose induction pathway regulates meiosis in Saccharomyces cerevisiae in part by controlling turnover of Ime2p meiotic kinase.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA replication origin binding	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA replication origin binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sporulation resulting in formation of a cellular spore	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein kinase IME2

NP_012429.1

EC 2.7.11.1

Serine/threonine protein kinase involved in activation of meiosis; associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; human CDK2 can complement ime2 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

221390..223327

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181539.1 → NP_012429.1 TPA: protein kinase IME2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012429.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW78, P32581

UniProtKB/TrEMBL

G2WGR2

Conserved Domains (1) summary

cd07830
Location:38 → 386

STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases