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    PHO86 Pho86p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853325, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PHO86
    Official Full Name
    Pho86p
    Primary source
    SGD:S000003653
    Locus tag
    YJL117W
    See related
    AllianceGenome:SGD:S000003653; FungiDB:YJL117W; VEuPathDB:YJL117W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein folding; and regulation of phosphate transport. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PHO86 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (192531..193466)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ribulose-phosphate 3-epimerase RPE1 Neighboring gene uncharacterized protein Neighboring gene SUN family protein NCA3 Neighboring gene nucleosome assembly factor ASF1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae, is required for ER exit of the high-affinity phosphate transporter Pho84p. Lau WT, et al. Proc Natl Acad Sci U S A, 2000 Feb 1. PMID 10655492, Free PMC Article
    2. Phosphate transporter mediated lipid accumulation in Saccharomyces cerevisiae under phosphate starvation conditions. James AW, et al. Bioresour Technol, 2014 Jan. PMID 24212129
    3. Two new genes, PHO86 and PHO87, involved in inorganic phosphate uptake in Saccharomyces cerevisiae. Bun-ya M, et al. Curr Genet, 1996 Mar. PMID 8598055
    4. A putative new membrane protein, Pho86p, in the inorganic phosphate uptake system of Saccharomyces cerevisiae. Yompakdee C, et al. Gene, 1996 May 24. PMID 8675028
    5. A genome-wide screen identifies yeast genes required for protection against or enhanced cytotoxicity of the antimalarial drug quinine. Dos Santos SC, et al. Mol Genet Genomics, 2011 Dec. PMID 21960436

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphate ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of phosphate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pho86p
    NP_012418.1
    • Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      192531..193466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181550.1 → NP_012418.1  TPA: Pho86p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012418.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW67, E9P8T7, P46956
      UniProtKB/TrEMBL
      A6ZQL2, B3LQ00, B5VL58, C7GQ09, C8ZBA2, G2WGQ4, N1P0K1
      Conserved Domains (1) summary
      pfam11124
      Location:23 → 302
      Pho86; Inorganic phosphate transporter Pho86
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46956.1

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