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    CDC6 AAA family ATPase CDC6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853244, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CDC6
    Official Full Name
    AAA family ATPase CDC6
    Primary source
    SGD:S000003730
    Locus tag
    YJL194W
    See related
    AllianceGenome:SGD:S000003730; FungiDB:YJL194W; VEuPathDB:YJL194W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables several functions, including DNA replication origin binding activity; purine ribonucleoside triphosphate binding activity; and ribonucleoside triphosphate phosphatase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and nuclear DNA replication. Located in cytoplasm and nucleus. Part of DNA replication preinitiation complex and nuclear pre-replicative complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CDC6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (69338..70879)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-specific protease UBP12 Neighboring gene fatty acid elongase ELO1 Neighboring gene uncharacterized protein Neighboring gene Sop4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DNA-A component of a plant geminivirus (Indian mung bean yellow mosaic virus) replicates in budding yeast cells. Raghavan V, et al. J Virol, 2004 Mar. PMID 14963136, Free PMC Article
    2. The CDC6 gene is required for centromeric, episomal, and 2-microns plasmid stability in the yeast Saccharomyces cerevisiae. Storici F, et al. Plasmid, 1995 Nov. PMID 8825371
    3. Intracellular location of the Saccharomyces cerevisiae CDC6 gene product. Jong A, et al. DNA Cell Biol, 1996 Oct. PMID 8892760
    4. In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization. Evrin C, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23376927, Free PMC Article
    5. Identification and characterization of Saccharomyces cerevisiae Cdc6 DNA-binding properties. Feng L, et al. Mol Biol Cell, 2000 May. PMID 10793143, Free PMC Article

    See all (200) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC.DNA.Cdc6.
      Title: A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
    2. Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
      Title: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
    3. The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6.
      Title: The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6.
    4. DNA replication origins retain mobile licensing proteins.
      Title: DNA replication origins retain mobile licensing proteins.
    5. The global role of cyclin-specific phosphorylation has been resolved whereby a cyclin docking motif, LxF, that mediates binding of replication factor Cdc6 to mitotic cyclin has been uncovered.
      Title: Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle.
    6. Repression of CDC6 and SLD2 during meiosis coincides with expression of shortened isoforms.
      Title: Transcriptional repression of CDC6 and SLD2 during meiosis is associated with production of short heterogeneous RNA isoforms.
    7. Cdc6 degradation triggered by Mck1 kinase was enhanced upon DNA damage.
      Title: Cdc6 degradation requires phosphodegron created by GSK-3 and Cdk1 for SCFCdc4 recognition in Saccharomyces cerevisiae.
    8. Cdc6 ATP hydrolysis is therefore required for Cdc6 disengagement from the pre-replicative complex after helicase loading to advance subsequent steps in helicase activation in vivo.
      Title: Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.
    9. Data indicate that Cdt1-MCM2-7 complex activates ORC/Cdc6 ATP-hydrolysis to promote helicase loading.
      Title: An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.
    10. We propose that both CDK and Mck1 kinases are required for Cdc6 degradation to ensure a tight control of DNA replication.
      Title: A yeast GSK-3 kinase Mck1 promotes Cdc6 degradation to inhibit DNA re-replication.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in MCM complex loading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication preinitiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    part_of nuclear pre-replicative complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AAA family ATPase CDC6
    NP_012341.1
    • Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; dual role as a mitotic cyclin-dependent kinase inhibitor, that binds to and inhibits Cdc28p/Clb2p along with Sic1p, contributing to mitotic exit; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; degraded in response to plasma membrane stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      69338..70879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181627.1 → NP_012341.1  TPA: AAA family ATPase CDC6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012341.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVZ7, P09119
      UniProtKB/TrEMBL
      A6ZQE2, C7GS16, C8ZB26, G2WGI3, N1P1K7
      Conserved Domains (1) summary
      COG1474
      Location:77 → 508
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09119.3

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