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    LOT5 Lot5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853652, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LOT5
    Official Full Name
    Lot5p
    Primary source
    SGD:S000001666
    Locus tag
    YKL183W
    See related
    AllianceGenome:SGD:S000001666; FungiDB:YKL183W; VEuPathDB:YKL183W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in mRNA cis splicing, via spliceosome. Located in cytoplasm and nucleus. Orthologous to human CLNS1A (chloride nucleotide-sensitive channel 1A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LOT5 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (98721..99641)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase SPE1 Neighboring gene uncharacterized protein Neighboring gene tetrafunctional fatty acid synthase subunit FAS1 Neighboring gene ribose phosphate diphosphokinase subunit PRS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple mechanisms regulate expression of low temperature responsive (LOT) genes in Saccharomyces cerevisiae. Zhang L, et al. Biochem Biophys Res Commun, 2001 May 4. PMID 11327734
    2. Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae. Mulder KW, et al. Genetics, 2007 May. PMID 17513889, Free PMC Article
    3. Transcriptome-wide binding sites for components of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1, Nab3, and Sen1. Creamer TJ, et al. PLoS Genet, 2011 Oct. PMID 22028667, Free PMC Article
    4. Complete DNA sequence of yeast chromosome XI. Dujon B, et al. Nature, 1994 Jun 2. PMID 8196765
    5. A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition. Ho KL, et al. PLoS Genet, 2015 Mar. PMID 25822502, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Lot5p
    NP_012738.1
    • hypothetical protein; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      98721..99641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179749.1 → NP_012738.1  TPA: Lot5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012738.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX18, P34234
      UniProtKB/TrEMBL
      B3LQS3, C7GJ27, G2WHL0, N1P2V5
      Conserved Domains (1) summary
      pfam03517
      Location:83 → 216
      Voldacs; Regulator of volume decrease after cellular swelling
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34234.1

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