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    SDS22 type 1 protein phosphatase-activating protein SDS22 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853641, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SDS22
    Official Full Name
    type 1 protein phosphatase-activating protein SDS22
    Primary source
    SGD:S000001676
    Locus tag
    YKL193C
    See related
    AllianceGenome:SGD:S000001676; FungiDB:YKL193C; VEuPathDB:YKL193C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EGP1
    Summary
    Enables protein phosphatase activator activity and protein serine/threonine phosphatase inhibitor activity. Involved in chromosome segregation and maintenance of protein location in nucleus. Located in nucleus. Part of protein phosphatase type 1 complex. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SDS22 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (78866..79882, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mia40p Neighboring gene threonine--tRNA ligase MST1 Neighboring gene acyl carrier protein Neighboring gene 2-(3-amino-3-carboxypropyl)histidine synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sds22p is a subunit of a stable isolatable form of protein phosphatase 1 (Glc7p) from Saccharomyces cerevisiae. Hong G, et al. Arch Biochem Biophys, 2000 Apr 15. PMID 10775415
    2. The Saccharomyces cerevisiae gene SDS22 encodes a potential regulator of the mitotic function of yeast type 1 protein phosphatase. MacKelvie SH, et al. Mol Cell Biol, 1995 Jul. PMID 7791785, Free PMC Article
    3. Essential functions of Sds22p in chromosome stability and nuclear localization of PP1. Peggie MW, et al. J Cell Sci, 2002 Jan 1. PMID 11801737
    4. DNA sequence analysis of the YCN2 region of chromosome XI in Saccharomyces cerevisiae. Chéret G, et al. Yeast, 1993 Jun. PMID 8394042
    5. The EGP1 gene may be a positive regulator of protein phosphatase type 1 in the growth control of Saccharomyces cerevisiae. Hisamoto N, et al. Mol Cell Biol, 1995 Jul. PMID 7791784, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ypi1 forms a complex with Glc7 and Sds22, another Glc7 regulatory subunit that targets the phosphatase to substrates involved in cell cycle control.
      Title: YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein phosphatase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of protein location in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase type 1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type 1 protein phosphatase-activating protein SDS22
    NP_012728.1
    • Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      78866..79882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179759.1 → NP_012728.1  TPA: type 1 protein phosphatase-activating protein SDS22 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012728.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX07, P36047
      UniProtKB/TrEMBL
      A6ZZD2, B3LQR2, C7GJ16, G2WHJ9
      Conserved Domains (3) summary
      sd00033
      Location:68 → 91
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:112 → 332
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      NF033190
      Location:42 → 174
      inl_like_NEAT_1; NEAT domain-containing leucine-rich repeat protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36047.1

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