U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MST1 threonine--tRNA ligase MST1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853640, updated on 29-Jun-2024

    Summary

    Gene symbol
    MST1
    Gene description
    threonine--tRNA ligase MST1
    Primary source
    FungiDB:YKL194C
    Locus tag
    YKL194C
    See related
    SGD:S000001677; AllianceGenome:SGD:S000001677; VEuPathDB:YKL194C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables threonine-tRNA ligase activity. Involved in mitochondrial threonyl-tRNA aminoacylation. Located in mitochondrion. Orthologous to human MRPL39 (mitochondrial ribosomal protein L39). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MST1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (77258..78646, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene palmitoyltransferase YKT6 Neighboring gene Mia40p Neighboring gene type 1 protein phosphatase-activating protein SDS22 Neighboring gene acyl carrier protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity, acting on a tRNA IEA
    Inferred from Electronic Annotation
    more info
     
    enables threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables threonine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables threonine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables threonine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial threonyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in threonyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    threonine--tRNA ligase MST1
    NP_012727.1
    • Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; lacks a typical editing domain, but has pre-transfer editing activity stimulated by the unusual tRNA-Thr

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      77258..78646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179760.1NP_012727.1  TPA: threonine--tRNA ligase MST1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX06, P07236
      UniProtKB/TrEMBL
      A0A8H4FBU7
      Conserved Domains (2) summary
      cd00771
      Location:44347
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:347459
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...