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    YRA2 Yra2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853666, updated on 2-Nov-2024

    Summary

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    Official Symbol
    YRA2
    Official Full Name
    Yra2p
    Primary source
    SGD:S000001697
    Locus tag
    YKL214C
    See related
    AllianceGenome:SGD:S000001697; FungiDB:YKL214C; VEuPathDB:YKL214C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in poly(A)+ mRNA export from nucleus. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See YRA2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (31082..31693, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene dihydroorotate dehydrogenase Neighboring gene 5-oxoprolinase Neighboring gene Doa1p Neighboring gene phosphatidylinositol-3-phosphatase SAC1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p. Zenklusen D, et al. Mol Cell Biol, 2001 Jul. PMID 11390651, Free PMC Article
    2. Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Zenklusen D, et al. Mol Cell Biol, 2002 Dec. PMID 12417727, Free PMC Article
    3. Single-molecule quantitation of RNA-binding protein occupancy and stoichiometry defines a role for Yra1 (Aly/REF) in nuclear mRNP organization. Asada R, et al. Cell Rep, 2023 Nov 28. PMID 37963019, Free PMC Article
    4. Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex. Hurt E, et al. Proc Natl Acad Sci U S A, 2004 Feb 17. PMID 14769921, Free PMC Article
    5. Biochemical and genetic characterization of Yra1p in budding yeast. Kashyap AK, et al. Yeast, 2005 Jan 15. PMID 15584090

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Yra2p
    NP_012708.1
    • Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      31082..31693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179779.1 → NP_012708.1  TPA: Yra2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012708.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A075, C7GIZ9, D6VWY9, E7Q5V8, P36036
      UniProtKB/TrEMBL
      G2WHI0, N1P267
      Conserved Domains (2) summary
      COG0724
      Location:1 → 195
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12295
      Location:64 → 137
      RRM_YRA2; RNA recognition motif in yeast RNA annealing protein YRA2 (Yra2p) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36036.1

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