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    SMF3 putative divalent metal ion transporter SMF3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850721, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SMF3
    Official Full Name
    putative divalent metal ion transporter SMF3
    Primary source
    SGD:S000004024
    Locus tag
    YLR034C
    See related
    AllianceGenome:SGD:S000004024; FungiDB:YLR034C; VEuPathDB:YLR034C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable cadmium ion transmembrane transporter activity and manganese ion transmembrane transporter activity. Involved in intracellular iron ion homeostasis and iron ion transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See SMF3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (210512..211933, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene DNA helicase RAD5 Neighboring gene Rsc58p Neighboring gene mismatch repair protein MLH2 Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The metalloreductase Fre6p in Fe-efflux from the yeast vacuole. Singh A, et al. J Biol Chem, 2007 Sep 28. PMID 17681937
    2. The family of SMF metal ion transporters in yeast cells. Cohen A, et al. J Biol Chem, 2000 Oct 27. PMID 10930410
    3. Overexpression, purification, and site-directed spin labeling of the Nramp metal transporter from Mycobacterium leprae. Reeve I, et al. Proc Natl Acad Sci U S A, 2002 Jun 25. PMID 12077319, Free PMC Article
    4. Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters. Portnoy ME, et al. Mol Cell Biol, 2000 Nov. PMID 11027260, Free PMC Article
    5. Regulation of Saccharomyces cerevisiae FET4 by oxygen and iron. Jensen LT, et al. J Mol Biol, 2002 Apr 26. PMID 12051835

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cadmium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic cation transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables manganese ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular manganese ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in manganese ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in manganese ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative divalent metal ion transporter SMF3
    NP_013134.1
    • Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of Nramp family of metal transport proteins; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      210512..211933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181921.2 → NP_013134.1  TPA: putative divalent metal ion transporter SMF3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013134.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY36, Q12078
      UniProtKB/TrEMBL
      A7A0U0, B3LT06, B5VMX1, C7GXH9, C8ZD06, G2WIM7, N1P036
      Conserved Domains (1) summary
      cl00456
      Location:10 → 402
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12078.1

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