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    NOP56 snoRNP complex protein NOP56 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850894, updated on 7-Jul-2024

    Summary

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    Gene symbol
    NOP56
    Gene description
    snoRNP complex protein NOP56
    Primary source
    FungiDB:YLR197W
    Locus tag
    YLR197W
    See related
    SGD:S000004187; AllianceGenome:SGD:S000004187; VEuPathDB:YLR197W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SIK1
    Summary
    Enables mRNA binding activity. Involved in rRNA processing. Located in nucleolus. Part of box C/D RNP complex and small-subunit processome. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 36. Orthologous to human NOP56 (NOP56 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NOP56 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (546097..547611)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene glycylpeptide N-tetradecanoyltransferase NMT1 Neighboring gene rRNA-processing protein PWP1 Neighboring gene Pba1p Neighboring gene tubulin-binding prefolding complex subunit YKE2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thermoplastic microfluidic bioreactors with integrated electrodes to study tumor treating fields on yeast cells. Gencturk E, et al. Biomicrofluidics, 2020 May. PMID 32477443, Free PMC Article
    2. Cell trapping microfluidic chip made of Cyclo olefin polymer enabling two concurrent cell biology experiments with long term durability. Gencturk E, et al. Biomed Microdevices, 2020 Feb 20. PMID 32078073
    3. A Drug Repurposing and Protein-Protein Interaction Network Study of Ribosomopathies Using Yeast as a Model System. Ertekin E, et al. OMICS, 2020 Feb. PMID 31895625
    4. Genetic analysis of growth inhibition by GAL4-L kappa B-alpha in Saccharomyces cerevisiae. Morin PJ, et al. Cell Growth Differ, 1995 Jul. PMID 7547500
    5. Real-Time Single-Cell Monitoring of Drug Effects Using Droplet-Based Microfluidic Technology: A Proof-of-Concept Study. Kasim M, et al. OMICS, 2021 Oct. PMID 34582730

    See all (136) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain.
      Title: High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA modification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of box C/D methylation guide snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box C/D methylation guide snoRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of box C/D methylation guide snoRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of box C/D methylation guide snoRNP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small-subunit processome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    snoRNP complex protein NOP56
    NP_013298.1
    • Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      546097..547611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182084.1 → NP_013298.1  TPA: snoRNP complex protein NOP56 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013298.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYK0, Q12460
      UniProtKB/TrEMBL
      A0A8H4BZG5, A7A187, B3RH88, B5VNB7, C7GIS9, C8ZDG3, G2WJ29, N1P1B4
      Conserved Domains (2) summary
      COG1498
      Location:48 → 447
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam08156
      Location:6 → 72
      NOP5NT; NOP5NT (NUC127) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12460.1

    Gene LinkOut

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