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    MSS51 Mss51p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850900, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MSS51
    Official Full Name
    Mss51p
    Primary source
    SGD:S000004193
    Locus tag
    YLR203C
    See related
    AllianceGenome:SGD:S000004193; FungiDB:YLR203C; VEuPathDB:YLR203C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables translation regulator activity. Involved in mitochondrial cytochrome c oxidase assembly and positive regulation of mitochondrial translation. Located in mitochondrion. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See MSS51 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (550650..551960, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tubulin-binding prefolding complex subunit YKE2 Neighboring gene ubiquinone biosynthesis protein COQ9 Neighboring gene mitochondrial 37S ribosomal protein QRI5 Neighboring gene Hmx1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MSS51 gene product is required for the translation of the COX1 mRNA in yeast mitochondria. Decoster E, et al. Mol Gen Genet, 1990 Oct. PMID 2177521
    2. Analysis of a yeast nuclear gene involved in the maturation of mitochondrial pre-messenger RNA of the cytochrome oxidase subunit I. Faye G, et al. Cell, 1983 Jan. PMID 6297789
    3. Mss51p, a putative translational activator of cytochrome c oxidase subunit-1 (COX1) mRNA, is required for synthesis of Cox1p in Saccharomyces cerevisiae. Siep M, et al. Curr Genet, 2000 Apr. PMID 10803883
    4. Steps in processing of the mitochondrial cytochrome oxidase subunit I pre-mRNA affected by a nuclear mutation in yeast. Simon M, et al. Proc Natl Acad Sci U S A, 1984 Jan. PMID 6320175, Free PMC Article
    5. Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiae. Zambrano A, et al. Mol Biol Cell, 2007 Feb. PMID 17135289, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The physical interaction OF Mss51 & Cox14 depends on Cox1 synthesis, showing dynamic assembly of early cytochrome c oxidase intermediates nucleated by Cox1.
      Title: Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces cerevisiae mitochondria.
    2. Ssc1, by interacting with Mss51 and Mss51-containing complexes, plays a critical role in Cox1 biogenesis, COX assembly, and the translational regulation of these processes.
      Title: Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis.
    3. These results support a key role for Mss51p in translationally regulating Cox1p synthesis by the status of cytochrome oxidase assembly.
      Title: Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mss51p
    NP_013304.1
    • Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      550650..551960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182090.1 → NP_013304.1  TPA: Mss51p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013304.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYK4, P32335
      UniProtKB/TrEMBL
      A7A191, B3RH92, B5VNC0, C7GIT3, G2WJ33, N1NZT5
      Conserved Domains (1) summary
      pfam13824
      Location:85 → 135
      zf-Mss51; Zinc-finger of mitochondrial splicing suppressor 51
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32335.2

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