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    CDC123 cell proliferation protein CDC123 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850912, updated on 17-May-2024

    Summary

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    Gene symbol
    CDC123
    Gene description
    cell proliferation protein CDC123
    Primary source
    FungiDB:YLR215C
    Locus tag
    YLR215C
    See related
    SGD:S000004205; AllianceGenome:SGD:S000004205; VEuPathDB:YLR215C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATP binding activity and magnesium ion binding activity. Involved in eukaryotic translation initiation factor 2 complex assembly and positive regulation of translational initiation. Located in cytoplasm. Orthologous to human CDC123 (cell division cycle 123). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CDC123 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (570776..571858, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative glycosylase Neighboring gene ferric/cupric-chelate reductase Neighboring gene peptidylprolyl isomerase CPR6 Neighboring gene Coa4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features. Panvert M, et al. Structure, 2015 Sep 1. PMID 26211610
    2. Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance. Bieganowski P, et al. J Biol Chem, 2004 Oct 22. PMID 15319434
    3. Translation initiation requires cell division cycle 123 (Cdc123) to facilitate biogenesis of the eukaryotic initiation factor 2 (eIF2). Perzlmaier AF, et al. J Biol Chem, 2013 Jul 26. PMID 23775072, Free PMC Article
    4. Stepwise assembly of the eukaryotic translation initiation factor 2 complex. Vanselow S, et al. J Biol Chem, 2022 Feb. PMID 35031321, Free PMC Article
    5. Evolution. Systematic humanization of yeast genes reveals conserved functions and genetic modularity. Kachroo AH, et al. Science, 2015 May 22. PMID 25999509, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDC123 may have a role in novel protein modifications
      Title: The eukaryotic translation initiation regulator CDC123 defines a divergent clade of ATP-grasp enzymes with a predicted role in novel protein modifications.
    2. Data indicate that Cdc123 is a specific assembly factor for eukaryotic translation initiation factor 2 (eIF) subunit alpha (sui2), subunit beta (sui3) and subunit gamma (GCD11), which is indispensable for the onset of protein synthesis.
      Title: Translation initiation requires cell division cycle 123 (Cdc123) to facilitate biogenesis of the eukaryotic initiation factor 2 (eIF2).
    3. the Cdc123-Chf-Gcd11 axis is an essential pathway for nutritional control of START that runs parallel to the Tor-Gcn2-Sui2 system of translational control
      Title: Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within eukaryotic translation initiation factor 2 complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell proliferation protein CDC123
    NP_013316.1
    • Assembly factor for the eIF2 translation initiation factor complex; regulates translational initiation; conserved residues of this ATP-Grasp protein that bind to ATP-Mg2+ in the pombe ortholog are required for complex assembly in budding yeast; interaction with eIF2 subunit Gcd11p facilitates complex assembly and activity; required for the START transition and timely progression through G2; regulated by nutrient availability; human ortholog complements the yeast mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      570776..571858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182102.1 → NP_013316.1  TPA: cell proliferation protein CDC123 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013316.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A1A3, D6VYL6, Q05791
      UniProtKB/TrEMBL
      A0A8H4BX77, C8ZDH9, N1NZE9
      Conserved Domains (1) summary
      pfam07065
      Location:27 → 328
      D123
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05791.1

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