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    DCS1 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850974, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DCS1
    Official Full Name
    5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase
    Primary source
    SGD:S000004260
    Locus tag
    YLR270W
    See related
    AllianceGenome:SGD:S000004260; FungiDB:YLR270W; VEuPathDB:YLR270W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables exoribonuclease activator activity and m7G(5')pppN diphosphatase activity. Involved in cellular response to starvation; nuclear-transcribed mRNA catabolic process; and positive regulation of exoribonuclease activity. Located in P-body. Orthologous to human DCPS (decapping enzyme, scavenger). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DCS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (681186..682238)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Bop2p Neighboring gene SNAP receptor SEC22 Neighboring gene Cmg1p Neighboring gene condensin subunit YCS4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast scavenger decapping enzyme DcpS and its application for in vitro RNA recapping. Wulf MG, et al. Sci Rep, 2019 Jun 13. PMID 31197197, Free PMC Article
    2. An excess of catalytically required motions inhibits the scavenger decapping enzyme. Neu A, et al. Nat Chem Biol, 2015 Sep. PMID 26258763, Free PMC Article
    3. Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme. Fuchs AL, et al. Proc Natl Acad Sci U S A, 2020 Aug 11. PMID 32723815, Free PMC Article
    4. Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies. Malys N, et al. J Mol Biol, 2006 Oct 20. PMID 16963086
    5. Scavenger decapping activity facilitates 5' to 3' mRNA decay. Liu H, et al. Mol Cell Biol, 2005 Nov. PMID 16260594, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data reveal a unique mechanism of mRNA substrate inhibition in which motions that are required for catalytic activity also inhibit efficient DCS1 turnover when they are present in excess.
      Title: An excess of catalytically required motions inhibits the scavenger decapping enzyme.
    2. We propose that the activation of Xrn1 by Dcs1 is important for respiration.
      Title: Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast.
    3. Dcs1p scavenger decapping enzyme enhances 5' to 3' mRNA decay
      Title: Scavenger decapping activity facilitates 5' to 3' mRNA decay.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exoribonuclease activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA methylguanosine-cap decapping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase
    NP_013372.1
    • Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; acts as inhibitor of neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress; DCS1 has a paralog, DCS2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      681186..682238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182157.1 → NP_013372.1  TPA: 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013372.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYR7, Q06151, Q6Q5L1
      UniProtKB/TrEMBL
      A7A1F1, B3RHF3, C7GQX1, C8ZDN4, G2WJ95, N1P6Z9
      Conserved Domains (1) summary
      COG5075
      Location:1 → 330
      COG5075; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06151.1

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