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    GCD7 translation initiation factor eIF2B subunit beta [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850998, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GCD7
    Official Full Name
    translation initiation factor eIF2B subunit beta
    Primary source
    SGD:S000004282
    Locus tag
    YLR291C
    See related
    AllianceGenome:SGD:S000004282; FungiDB:YLR291C; VEuPathDB:YLR291C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme regulator activity and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in regulation of translational initiation. Located in cytosol and mitochondrion. Part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 2. Orthologous to human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GCD7 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (718317..719462, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene GTPase GUF1 Neighboring gene ubiquinone biosynthesis protein COQ11 Neighboring gene Sec63 complex subunit SEC72 Neighboring gene Ran GTPase GSP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Bushman JL, et al. Mol Cell Biol, 1993 Mar. PMID 8441423, Free PMC Article
    2. Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation. Krishnamoorthy T, et al. Mol Cell Biol, 2001 Aug. PMID 11438658, Free PMC Article
    3. Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome. Hinnebusch AG. J Biol Chem, 1997 Aug 29. PMID 9268289
    4. Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required for optimal eIF-2 function in S. cerevisiae. Feng L, et al. Mol Cell Biol, 1994 Aug. PMID 8035796, Free PMC Article
    5. Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation. Vazquez de Aldana CR, et al. Mol Cell Biol, 1994 May. PMID 8164676, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings provide compelling evidence that beta/Gcd7 is crucial for binding of substrate by eIF2B in vivo, beyond its dispensable regulatory role in the inhibition of eIF2B by eIF
      Title: The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo.
    2. The eIF2/eIF5 complex represents a cytoplasmic reservoir for eIF2 that antagonizes eIF2B-promoted guanine nucleotide exchange, enabling coordinated regulation of translation initiation.
      Title: An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation.
    3. These data show that multiple contacts between eIF2gamma and eIF2Bepsilon mediate nucleotide exchange.
      Title: Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables enzyme regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to guanyl-nucleotide exchange factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translational initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translational initiation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2B complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2B complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2B complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 2B complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    translation initiation factor eIF2B subunit beta
    NP_013394.1
    • Beta subunit of translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as negative regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog can complement yeast mutant, allows growth down-regulation of yeast gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      718317..719462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182179.1 → NP_013394.1  TPA: translation initiation factor eIF2B subunit beta [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013394.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYT7, P32502
      UniProtKB/TrEMBL
      A7A1H4, B3RHH1, B5VNJ7, C7GVU6, C8ZDQ5, G2WJB5, N1NZZ0
      Conserved Domains (1) summary
      COG1184
      Location:17 → 370
      GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32502.1

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