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    CSR1 Csr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851096, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CSR1
    Official Full Name
    Csr1p
    Primary source
    SGD:S000004372
    Locus tag
    YLR380W
    See related
    AllianceGenome:SGD:S000004372; FungiDB:YLR380W; VEuPathDB:YLR380W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SFH2
    Summary
    Enables phosphatidylinositol transfer activity. Involved in several processes, including Golgi to plasma membrane protein transport; phosphatidylinositol metabolic process; and regulation of lipid biosynthetic process. Located in cytosol; endosome; and lipid droplet. Orthologous to human MOSPD2 (motile sperm domain containing 2). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See CSR1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (878282..879508)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene translocon subunit SEC61 Neighboring gene uncharacterized protein Neighboring gene Ctf3p Neighboring gene leucine--tRNA ligase NAM2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily. Chen L, et al. Acta Crystallogr D Struct Biol, 2022 Jul 1. PMID 35775985
    2. SFH2 regulates fatty acid synthase activity in the yeast Saccharomyces cerevisiae and is critical to prevent saturated fatty acid accumulation in response to haem and oleic acid depletion. Desfougères T, et al. Biochem J, 2008 Jan 1. PMID 17803462
    3. The protein interaction of Saccharomyces cerevisiae cytoplasmic thiol peroxidase II with SFH2p and its in vivo function. Cha MK, et al. J Biol Chem, 2003 Sep 12. PMID 12824182
    4. Identification of a putative DEAD-box RNA helicase and a zinc-finger protein in Candida albicans by functional complementation of the S. cerevisiae rok1 mutation. Kim WI, et al. Yeast, 2000 Mar 30. PMID 10705369
    5. Sec14p-like proteins regulate phosphoinositide homoeostasis and intracellular protein and lipid trafficking in yeast. Mousley CJ, et al. Biochem Soc Trans, 2006 Jun. PMID 16709158

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
      Title: Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
    2. Sfh2p inhibits fatty acid synthase activity in response to haem depletion
      Title: SFH2 regulates fatty acid synthase activity in the yeast Saccharomyces cerevisiae and is critical to prevent saturated fatty acid accumulation in response to haem and oleic acid depletion.
    3. This review describes how overexpression of Sec14p-like protein SFH2 (Sec Fourteen Homologue 2) rescues sec14-1(temperature-sensitive)-associated growth and secretory defects.
      Title: Sec14p-like proteins regulate phosphoinositide homoeostasis and intracellular protein and lipid trafficking in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylinositol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of phosphatidylglycerol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylcholine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    Csr1p
    NP_013484.3
    • Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      878282..879508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182269.3 → NP_013484.3  TPA: Csr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013484.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ15, Q06705, Q6B265
      UniProtKB/TrEMBL
      A7A1Q5, B3RHP5, B5VNR6, C7GXI4, C8ZDZ0, G2WJJ5, N1NZS0
      Conserved Domains (2) summary
      pfam00650
      Location:168 → 312
      CRAL_TRIO; CRAL/TRIO domain
      pfam03765
      Location:82 → 130
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06705.1

    Gene LinkOut

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