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    APT1 adenine phosphoribosyltransferase APT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854986, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APT1
    Official Full Name
    adenine phosphoribosyltransferase APT1
    Primary source
    SGD:S000004484
    Locus tag
    YML022W
    See related
    AllianceGenome:SGD:S000004484; FungiDB:YML022W; VEuPathDB:YML022W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables adenine phosphoribosyltransferase activity. Involved in adenine salvage. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See APT1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (228937..229500)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S17A Neighboring gene Smc5-Smc6 complex subunit NSE5 Neighboring gene uracil-DNA glycosylase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, purification, crystallization and preliminary X-ray diffraction crystallographic study of acyl-protein thioesterase 1 from Saccharomyces cerevisiae. Yuan Y, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Jul 1. PMID 22750862, Free PMC Article
    2. Purification and characterization of adenine phosphoribosyltransferase from Saccharomyces cerevisiae. Alfonzo JD, et al. Biochim Biophys Acta, 1997 Sep 5. PMID 9357956
    3. Cloning and characterization of the adenine phosphoribosyltransferase-encoding gene (APT1) from Saccharomyces cerevisiae. Alfonzo JD, et al. Gene, 1995 Aug 8. PMID 7642142
    4. Mutants of Saccharomyces cerevisiae deficient in adenine phosphoribosyltransferase. Sahota A, et al. Mutat Res, 1987 Sep. PMID 3306356
    5. Chemical Chaperones Modulate the Formation of Metabolite Assemblies. Adsi H, et al. Int J Mol Sci, 2021 Aug 25. PMID 34502079, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro.
      Title: The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro.
    2. crystals of Apt1 diffracted to 2.40 A resolution and belonged to space group P4(2)2(1)2, with unit-cell parameters a = b = 146.43, c = 93.29 A
      Title: Cloning, purification, crystallization and preliminary X-ray diffraction crystallographic study of acyl-protein thioesterase 1 from Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenine salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenine salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenine salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenine phosphoribosyltransferase APT1
    NP_013690.1
    • Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      228937..229500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182380.1 → NP_013690.1  TPA: adenine phosphoribosyltransferase APT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013690.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZF2, P49435, Q6Q5A3
      UniProtKB/TrEMBL
      A6ZM40, B3LLN0, B5VPA4, C7GLE0, C8ZEI2, G2WK30, N1P593
      Conserved Domains (1) summary
      TIGR01090
      Location:10 → 180
      apt; adenine phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49435.3

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