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    UBX4 Ubx4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855089, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UBX4
    Official Full Name
    Ubx4p
    Primary source
    SGD:S000004671
    Locus tag
    YMR067C
    See related
    AllianceGenome:SGD:S000004671; FungiDB:YMR067C; VEuPathDB:YMR067C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CUI1
    Summary
    Involved in sporulation resulting in formation of a cellular spore and ubiquitin-dependent ERAD pathway. Located in nucleus. Is extrinsic component of membrane. Human ortholog(s) of this gene implicated in alveolar soft part sarcoma. Orthologous to human ASPSCR1 (ASPSCR1 tether for SLC2A4, UBX domain containing). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UBX4 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (404323..405573, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Kar5p Neighboring gene Sov1p Neighboring gene Avo2p Neighboring gene N-terminal L-serine N(alpha)-acetyltransferase NatD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comparative genomic approach for identifying synthetic lethal interactions in human cancer. Deshpande R, et al. Cancer Res, 2013 Oct 15. PMID 23980094, Free PMC Article
    2. Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. Alberts SM, et al. J Biol Chem, 2009 Jun 12. PMID 19359248, Free PMC Article
    3. The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. De-Souza EA, et al. J Biol Chem, 2020 Mar 20. PMID 31996377, Free PMC Article
    4. Binding of Cdc48p to a ubiquitin-related UBX domain from novel yeast proteins involved in intracellular proteolysis and sporulation. Decottignies A, et al. Yeast, 2004 Jan 30. PMID 14755638
    5. Deviation of the typical AAA substrate-threading pore prevents fatal protein degradation in yeast Cdc48. Esaki M, et al. Sci Rep, 2017 Jul 14. PMID 28710470, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response.
      Title: The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response.
    2. Cdc48-Ubx4 acts on the proteasome and uses the chaperone activity to promote its nuclear distribution, thereby optimizing the proteasome level for efficient degradation of mitotic regulators.
      Title: Cdc48 chaperone and adaptor Ubx4 distribute the proteasome in the nucleus for anaphase proteolysis.
    3. The observation that Ubx2 and Ubx4 are not found together in one complex with Cdc48 suggests several distinct steps in modulating the activity and localization of Cdc48 in endoplasmic reciculum
      Title: Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubx4p
    NP_013783.1
    • UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the role of the Cdc48p-Nplp-Ufd1p AAA ATPase complex in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress; human ortholog ASPSCR1 partially complements the yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      404323..405573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182565.1 → NP_013783.1  TPA: Ubx4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013783.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZP1, P54730
      UniProtKB/TrEMBL
      C7GL57, C8ZER9, N1NYP7
      Conserved Domains (2) summary
      smart00166
      Location:277 → 351
      UBX; Domain present in ubiquitin-regulatory proteins
      cd16105
      Location:4 → 74
      Ubl_ASPSCR1_like; Ubiquitin-like (Ubl) domain found at the N-terminus of mammalian ASPSCR1 (alveolar soft part sarcoma chromosomal region candidate gene 1 protein), Saccharomyces cerevisie Ubx4p, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54730.1

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